J Cancer 2020; 11(21):6226-6233. doi:10.7150/jca.46613 This issue

Review

miR-552: an important post-transcriptional regulator that affects human cancer

Yuhao Zou, Xin Zhao, Yin Li, Shiwei Duan

Medical Genetics Center, Ningbo University School of Medicine, Ningbo, Zhejiang, China.

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Citation:
Zou Y, Zhao X, Li Y, Duan S. miR-552: an important post-transcriptional regulator that affects human cancer. J Cancer 2020; 11(21):6226-6233. doi:10.7150/jca.46613. Available from https://www.jcancer.org/v11p6226.htm

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Abstract

MiR-552 is a small non-coding RNA located on chromosome 1p34.3, and its expression level is significantly up-regulated in tissues or cells of various tumors. miR-552 can target multiple genes. These targeted genes play important regulatory roles in biological processes such as gene transcription and translation, cell cycle progression, cell proliferation, apoptosis, cell migration, and invasion. Besides, miR-552 may affect the efficacy of various anticancer drugs by targeting genes such as TP53 and RUNX3. This review summarizes the biological functions and clinical expressions of miR-552 in human cancer. Our goal is to explore the potential value of miR-552 in the diagnosis, prognosis, and treatment of human cancer.

Keywords: miR-552, cancer, diagnosis, prognosis, drug resistance