MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers

Zhou, Meng; Wu, Yuncui; Li, Hongwu; Zha, Xiaojun

doi:10.7150/jca.46293

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2020; 11(22):6716-6726. doi:10.7150/jca.46293 This issue Cite

Review

MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers

Meng Zhou¹, Yuncui Wu¹, Hongwu Li^2✉, Xiaojun Zha^1✉

1. Department of Biochemistry & Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China.
2. Department of Otorhinolaryngology, Head & Neck Surgery, The Fourth Affiliated Hospital of Anhui Medical University, Hefei 230000, China.

Citation:

Zhou M, Wu Y, Li H, Zha X. MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers. J Cancer 2020; 11(22):6716-6726. doi:10.7150/jca.46293. https://www.jcancer.org/v11p6716.htm

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Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. It has been reported that microRNA-144 (miR-144) is highly conserved and can combine complementarily with the 3'-UTRs of target gene mRNAs to inhibit mRNA translation or promote targeted mRNA degradation. MiR-144 is abnormally expressed and has been identified as a tumor suppressor in many types of solid tumors. Increasing evidence supports a crucial role for miR-144 in modulating physiopathologic processes, such as proliferation, apoptosis, invasion, migration and angiogenesis in different tumor cells. Apart from these functions, miR-144 can also affect drug sensitivity, cancer treatment and patient prognosis. In this review, we summarize the biological functions of miR-144, its direct targets and the important signal pathways through which it acts in relation to various tumors. We also discuss the role of miR-144 in tumor biology and its clinical significance in detail and offer novel insights into molecular targeting therapy for human cancers.

Keywords: miRNA, miR-144, tumor development, cancer diagnosis, cancer prognosis, cancer treatment

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APA

Zhou, M., Wu, Y., Li, H., Zha, X. (2020). MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers. Journal of Cancer, 11(22), 6716-6726. https://doi.org/10.7150/jca.46293.

ACS

Zhou, M.; Wu, Y.; Li, H.; Zha, X. MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers. J. Cancer 2020, 11 (22), 6716-6726. DOI: 10.7150/jca.46293.

NLM

CSE

Zhou M, Wu Y, Li H, Zha X. 2020. MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers. J Cancer. 11(22):6716-6726.

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