Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis

Jiang, Xiaowen; Hui, Fuhai; Qin, Xiaochun; Wu, Yuting; Liu, Haihan; Gao, Jing; Li, Xiang; Xu, Yali; Zhang, Yingshi

doi:10.7150/jca.49970

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J Cancer 2020; 11(24):7091-7100. doi:10.7150/jca.49970 This issue Cite

Review

Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis

Xiaowen Jiang^1#, Fuhai Hui^1#, Xiaochun Qin¹, Yuting Wu¹, Haihan Liu¹, Jing Gao², Xiang Li², Yali Xu², Yingshi Zhang^1✉

1. Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, 110016, China.
2. Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
#Xiaowen Jiang and Fuhai Hui contributed equally to this article

Citation:

Jiang X, Hui F, Qin X, Wu Y, Liu H, Gao J, Li X, Xu Y, Zhang Y. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J Cancer 2020; 11(24):7091-7100. doi:10.7150/jca.49970. https://www.jcancer.org/v11p7091.htm

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Abstract

Objective: To evaluate the diagnosis accuracy and prognostic significance of bio-marker dickkopf-1(DKK-1) protein in GIC, and also sub-type of hepatocellular carcinoma (HCC), pancreas carcinomas (PC), oesophageal carcinoma (EPC) and Adenocarcinoma of esophago-gastric junction (AEGJ), etc.

Methods: Electronic databases were searched from inception to May 2020. Patients were diagnosed with gastrointestinal carcinomas, and provided data on the correlation between high and low DKK-1 expression and diagnosis or prognosis.

Results: Forty-three publications involving 9318 participants were included in the network meta-analysis, with 31 of them providing data for diagnosis value and 18 records were eligible for providing prognosis value of DKK-1. DKK-1 has a moderate diagnostic value for overall GIC, HCC and PC. In addition, for the combined diagnosis value of DKK-1 +AFP, high diagnostic accuracy value could be determined in HCC and early HCC group, respectively. Whereas, diagnosis efficiency of DKK-1+CA19-9 was also better than that of DKK-1 alone with AUC value is above 0.95. For the prognosis meta-analysis of histopathological stratification, we found that EPC and AEGJ ranked the best for the histopathological stratification of prognosis from network meta-analysis. This systematic review protocol was registered with the PROSPERO registry (No.CRD42020167910).

Conclusion: DKK-1 has good diagnostic accuracy, especially combination of DKK-1+AFP in HCC and DKK-1+CA19-9 in PC, whereas modest prognostic significant in GIC. Future head-to-head researches are warranted for DKK-1 expression in HCC and PC tissue.

Keywords: DKK-1, Gastrointestinal carcinomas, Diagnosis, Prognostic, Network meta-analysis

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APA

Jiang, X., Hui, F., Qin, X., Wu, Y., Liu, H., Gao, J., Li, X., Xu, Y., Zhang, Y. (2020). Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. Journal of Cancer, 11(24), 7091-7100. https://doi.org/10.7150/jca.49970.

ACS

Jiang, X.; Hui, F.; Qin, X.; Wu, Y.; Liu, H.; Gao, J.; Li, X.; Xu, Y.; Zhang, Y. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J. Cancer 2020, 11 (24), 7091-7100. DOI: 10.7150/jca.49970.

NLM

CSE

Jiang X, Hui F, Qin X, Wu Y, Liu H, Gao J, Li X, Xu Y, Zhang Y. 2020. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J Cancer. 11(24):7091-7100.

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