J Cancer 2020; 11(24):7091-7100. doi:10.7150/jca.49970 This issue Cite

Review

Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis

Xiaowen Jiang1#, Fuhai Hui1#, Xiaochun Qin1, Yuting Wu1, Haihan Liu1, Jing Gao2, Xiang Li2, Yali Xu2, Yingshi Zhang1✉

1. Department of Life Science and Biochemistry, Shenyang Pharmaceutical University, Shenyang, 110016, China.
2. Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, China.
#Xiaowen Jiang and Fuhai Hui contributed equally to this article

Citation:
Jiang X, Hui F, Qin X, Wu Y, Liu H, Gao J, Li X, Xu Y, Zhang Y. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J Cancer 2020; 11(24):7091-7100. doi:10.7150/jca.49970. https://www.jcancer.org/v11p7091.htm
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Abstract

Objective: To evaluate the diagnosis accuracy and prognostic significance of bio-marker dickkopf-1(DKK-1) protein in GIC, and also sub-type of hepatocellular carcinoma (HCC), pancreas carcinomas (PC), oesophageal carcinoma (EPC) and Adenocarcinoma of esophago-gastric junction (AEGJ), etc.

Methods: Electronic databases were searched from inception to May 2020. Patients were diagnosed with gastrointestinal carcinomas, and provided data on the correlation between high and low DKK-1 expression and diagnosis or prognosis.

Results: Forty-three publications involving 9318 participants were included in the network meta-analysis, with 31 of them providing data for diagnosis value and 18 records were eligible for providing prognosis value of DKK-1. DKK-1 has a moderate diagnostic value for overall GIC, HCC and PC. In addition, for the combined diagnosis value of DKK-1 +AFP, high diagnostic accuracy value could be determined in HCC and early HCC group, respectively. Whereas, diagnosis efficiency of DKK-1+CA19-9 was also better than that of DKK-1 alone with AUC value is above 0.95. For the prognosis meta-analysis of histopathological stratification, we found that EPC and AEGJ ranked the best for the histopathological stratification of prognosis from network meta-analysis. This systematic review protocol was registered with the PROSPERO registry (No.CRD42020167910).

Conclusion: DKK-1 has good diagnostic accuracy, especially combination of DKK-1+AFP in HCC and DKK-1+CA19-9 in PC, whereas modest prognostic significant in GIC. Future head-to-head researches are warranted for DKK-1 expression in HCC and PC tissue.

Keywords: DKK-1, Gastrointestinal carcinomas, Diagnosis, Prognostic, Network meta-analysis


Citation styles

APA
Jiang, X., Hui, F., Qin, X., Wu, Y., Liu, H., Gao, J., Li, X., Xu, Y., Zhang, Y. (2020). Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. Journal of Cancer, 11(24), 7091-7100. https://doi.org/10.7150/jca.49970.

ACS
Jiang, X.; Hui, F.; Qin, X.; Wu, Y.; Liu, H.; Gao, J.; Li, X.; Xu, Y.; Zhang, Y. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J. Cancer 2020, 11 (24), 7091-7100. DOI: 10.7150/jca.49970.

NLM
Jiang X, Hui F, Qin X, Wu Y, Liu H, Gao J, Li X, Xu Y, Zhang Y. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J Cancer 2020; 11(24):7091-7100. doi:10.7150/jca.49970. https://www.jcancer.org/v11p7091.htm

CSE
Jiang X, Hui F, Qin X, Wu Y, Liu H, Gao J, Li X, Xu Y, Zhang Y. 2020. Diagnosis Accuracy and Prognostic Significance of the Dickkopf-1 Protein in Gastrointestinal Carcinomas: Systematic Review and Network Meta-analysis. J Cancer. 11(24):7091-7100.

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