The Essential Factors of Establishing Patient-derived Tumor Model

Chen, Chuanzhi; Lin, Wu; Huang, Yingying; Chen, Xiangliu; Wang, Haohao; Teng, Lisong

doi:10.7150/jca.51749

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

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J Cancer 2021; 12(1):28-37. doi:10.7150/jca.51749 This issue Cite

Review

The Essential Factors of Establishing Patient-derived Tumor Model

Chuanzhi Chen, Wu Lin, Yingying Huang, Xiangliu Chen, Haohao Wang, Lisong Teng^✉

Department of Surgical Oncology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Citation:

Chen C, Lin W, Huang Y, Chen X, Wang H, Teng L. The Essential Factors of Establishing Patient-derived Tumor Model. J Cancer 2021; 12(1):28-37. doi:10.7150/jca.51749. https://www.jcancer.org/v12p0028.htm

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Abstract

Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research discoveries and to test potential therapeutic approaches. However, research in this field is hampered by the limited engraftment rate. In this review, we go over a large number of researches on patient-derived xenograft transplantation and firstly systematically summarize the main factors in methodology to successfully establish models. These results will be applied to the development of patient-derived xenograft leading to better preclinical research.

Keywords: patient-derived xenograft, take rate, engraftment rate, tumor burden, Hormonal supplements, Humanized mouse

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APA

Chen, C., Lin, W., Huang, Y., Chen, X., Wang, H., Teng, L. (2021). The Essential Factors of Establishing Patient-derived Tumor Model. Journal of Cancer, 12(1), 28-37. https://doi.org/10.7150/jca.51749.

ACS

Chen, C.; Lin, W.; Huang, Y.; Chen, X.; Wang, H.; Teng, L. The Essential Factors of Establishing Patient-derived Tumor Model. J. Cancer 2021, 12 (1), 28-37. DOI: 10.7150/jca.51749.

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CSE

Chen C, Lin W, Huang Y, Chen X, Wang H, Teng L. 2021. The Essential Factors of Establishing Patient-derived Tumor Model. J Cancer. 12(1):28-37.

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