Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis

Fu, Jun; Ding, Zongren; Chen, Qinjunjie; Lin, Kongying; Liu, Hongzhi; Gao, Yuzhen; Zeng, Yongyi; Li, Haitao; Shen, Feng; Liu, Jingfeng

doi:10.7150/jca.47125



International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

Global reach, higher impact

Full Text | PDF

J Cancer 2021; 12(1):170-180. doi:10.7150/jca.47125 This issue Cite

Research Paper

Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis

Jun Fu^1,2*, Zongren Ding^1,2*, Qinjunjie Chen^3*, Kongying Lin^1,2, Hongzhi Liu^1,2, Yuzhen Gao⁴, Yongyi Zeng¹, Haitao Li¹, Feng Shen^3✉, Jingfeng Liu^1✉

1. Department of Hepatopancreatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, China.
2. The Big Data Institute of Southeast Hepatobiliary Health Information, Fuzhou, China.
3. Department of Hepatic Surgery IV, the Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
4. Department of Laboratory Medicine, the Eastern Hepatobiliary Surgery Hospital, Naval Medical University, Shanghai, China.
*These authors contributed equally to this work.

Citation:

Fu J, Ding Z, Chen Q, Lin K, Liu H, Gao Y, Zeng Y, Li H, Shen F, Liu J. Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis. J Cancer 2021; 12(1):170-180. doi:10.7150/jca.47125. https://www.jcancer.org/v12p0170.htm

Other styles

Abstract

Background: The effect of anti-viral treatment (AVT) initiated before surgery (pre-operative AVT) on HBV-related hepatocellular carcinoma (HCC) has been controversial. This study aimed to elucidate the prognostic significance of pre-operative AVT for HCC patients who received hepatectomy.

Materials and Methods: A large-scale retrospective study was conducted based on a cohort consisting of 1937 HBV-related HCC patients who underwent R0 liver resection between January 2011 and December 2012. Propensity score matching (PSM) method was adopted to balance covariates and landmark survival analyses were performed to visualize effects in different phases after surgery.

Results: After PSM, a total of matched 744 patients (372 in each group) were recruited. The patients in the pre-operative AVT group had lower HBV-DNA loading levels and better recurrence-free survival (RFS) than those in the non-AVT group. The 1, 3, 5-year RFS rates of two groups were 67.3%, 49.0%, and 43.1% vs. 66.7%, 41.1% and 18.5%, respectively (P<0.001). Landmark survival analyses demonstrated that pre-operative AVT could improve RFS, and the effect was beginning to show after the first 12 months. There was no significant difference of overall survival (OS) between the two groups (P=0.543), and the landmark survival analyses indicated that pre-operative AVT could improve OS and this effect was beginning to show after 36 months. Additionally, multivariate Cox regression analyses revealed that larger tumor (>5cm), esophageal and gastric varices, lymph node metastasis were independent risk factors of RFS, and larger tumor (>5cm) and ascites were independent risk factors of OS.

Conclusions: Pre-operative AVT could significantly improve the RFS, and could not improve short-term OS (< 36 months) but could better long-term survival of the patients with HBV-HCC after surgery.

Keywords: Anti-viral treatment, HBV-related HCC, Surgery, Long-term Prognosis

Citation styles

APA

Fu, J., Ding, Z., Chen, Q., Lin, K., Liu, H., Gao, Y., Zeng, Y., Li, H., Shen, F., Liu, J. (2021). Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis. Journal of Cancer, 12(1), 170-180. https://doi.org/10.7150/jca.47125.

ACS

Fu, J.; Ding, Z.; Chen, Q.; Lin, K.; Liu, H.; Gao, Y.; Zeng, Y.; Li, H.; Shen, F.; Liu, J. Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis. J. Cancer 2021, 12 (1), 170-180. DOI: 10.7150/jca.47125.

NLM

CSE

Fu J, Ding Z, Chen Q, Lin K, Liu H, Gao Y, Zeng Y, Li H, Shen F, Liu J. 2021. Distinct Impacts of Pre-Operative Antiviral Treatment on Post-Operative Outcomes of HBV-related Hepatocellular Carcinoma: A Landmark Analysis. J Cancer. 12(1):170-180.

This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.