J Cancer 2021; 12(4):1154-1160. doi:10.7150/jca.51537 This issue


An update in clinical utilization of photodynamic therapy for lung cancer

Kai Wang1, Boxin Yu1, Janak L. Pathak2✉

1. International Medicine Center, Tianjin Hospital, 406 south of JieFang road, HeXi District, Tianjin, China
2. Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou 510182, China

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Wang K, Yu B, Pathak JL. An update in clinical utilization of photodynamic therapy for lung cancer. J Cancer 2021; 12(4):1154-1160. doi:10.7150/jca.51537. Available from https://www.jcancer.org/v12p1154.htm

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Lung cancer is one of the leading causes of cancer-related death worldwide, with nearly 1.8 million-diagnosis and 1.59 million deaths. Surgery, radiotherapy, and chemotherapy in individual or combination are commonly used to treat lung cancers. Photodynamic therapy (PDT) is a highly selective method for the destruction of cancer cells by exerting cytotoxic activity on malignant cells. PDT has been the subject of numerous clinical studies and has proven to be an effective strategy for cancer therapy. Clinical studies revealed that PDT could prolong survival in patients with inoperable cancers and significantly improve quality of life. For inoperable lung cancer cases, PDT could be an effective therapy. Despite the clinical success reported, PDT is still currently underutilized to treat lung cancer and other tumors. PTD is still a new treatment approach for lung cancer mainly due to the lack of enough clinical research evaluating its' effectiveness and side effects. In this review, we discuss the current prospects and future potentials of PDT in lung cancer treatment.

Keywords: Photodynamic therapy, lung cancer, inoperable cancer, cancer treatment