J Cancer
2021; 12(6):1678-1686.
doi:10.7150/jca.50888 This issueCite
Research Paper
circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway
Wei Zhang, Gang Wu, Peichun Sun✉, Yuanzeng Zhu, Han Zhang
Department of Gastrointestinal Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, People's Republic of China.
✉ Corresponding author: Peichun Sun; Department of Gastrointestinal Surgery, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, School of Clinical Medicine, Henan University, No.7, Weiwu Road, Zhengzhou, Henan 450003, People's Republic of China. E-mail: spring0630spccom or xujinhongedu.cnMore
Citation:
Zhang W, Wu G, Sun P, Zhu Y, Zhang H. circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. J Cancer 2021; 12(6):1678-1686. doi:10.7150/jca.50888. https://www.jcancer.org/v12p1678.htm
Circular RNAs (circRNAs) are associated with various diseases, including cancers. However, their roles in colorectal cancer (CRC) have not been established. Hsa_circ_0000847 (circ_SMAD2) is a novel circRNA that was found to be elevated in CRC cell lines and tissues. High circ_SMAD2 levels were positively correlated with CRC clinicopathological features. Functional assays revealed that circ_SMAD2 enhanced CRC cell invasion, proliferation, and tumor growth. Mechanistically, circ_SMAD2 elevated Ribophorin II (RPN2) levels by inhibiting miR-1258. Therefore, circ_SMAD2 is a potential indicator for CRC progression.
Zhang, W., Wu, G., Sun, P., Zhu, Y., Zhang, H. (2021). circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. Journal of Cancer, 12(6), 1678-1686. https://doi.org/10.7150/jca.50888.
ACS
Zhang, W.; Wu, G.; Sun, P.; Zhu, Y.; Zhang, H. circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. J. Cancer 2021, 12 (6), 1678-1686. DOI: 10.7150/jca.50888.
NLM
Zhang W, Wu G, Sun P, Zhu Y, Zhang H. circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. J Cancer 2021; 12(6):1678-1686. doi:10.7150/jca.50888. https://www.jcancer.org/v12p1678.htm
CSE
Zhang W, Wu G, Sun P, Zhu Y, Zhang H. 2021. circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway. J Cancer. 12(6):1678-1686.
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