Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer

Ye, Jia-hui; Wang, Xiao-hua; Shi, Jia-jun; Yin, Xi; Chen, Cheng; Chen, Yan; Wu, Hong-Yan; Jiong, Shi; sun, Qi; Zhang, Meng; Shi, Xian-biao; Zhou, Guo-ren; Hassan, Shahzeb; Feng, Ji-feng; Xu, Xin-yun; Zhang, Wei-jie

doi:10.7150/jca.47566

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J Cancer 2021; 12(10):2886-2892. doi:10.7150/jca.47566 This issue Cite

Research Paper

Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer

Jia-hui Ye^1*, Xiao-hua Wang^2*, Jia-jun Shi^1*, Xi Yin^1*, Cheng Chen³, Yan Chen⁴, Hong-Yan Wu⁵, Shi Jiong⁵, Qi sun⁵, Meng Zhang¹, Xian-biao Shi¹, Guo-ren Zhou⁶, Shahzeb Hassan⁷, Ji-feng Feng^2✉, Xin-yun Xu^5✉, Wei-jie Zhang^1✉

1. Dept. of General Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
2. Dept. of Medical Oncology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
3. Dept. of Radiotherapy, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
4. Dept. of Pathology, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
5. Dept. of Pathology, Affiliated Drum tower Hospital of Nanjing University Medical School, Nanjing, China.
6. Dept. of Breast Surgery, Jiangsu Cancer Hospital Affiliated to Nanjing Medical University, Nanjing, China.
7. Northwestern University Feinberg School of Medicine, Chicago 60611, IL, United States.
*These authors contributed equally to this study.

Citation:

Ye Jh, Wang Xh, Shi Jj, Yin X, Chen C, Chen Y, Wu HY, Jiong S, sun Q, Zhang M, Shi Xb, Zhou Gr, Hassan S, Feng Jf, Xu Xy, Zhang Wj. Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer. J Cancer 2021; 12(10):2886-2892. doi:10.7150/jca.47566. https://www.jcancer.org/v12p2886.htm

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Abstract

Background and objective: Tumor-associated macrophages (TAMs) play an essential role in tumor progression and metastasis. However, the role of TAMs in neoadjuvant chemotherapy (NAC) is unclear and need to be identified. The main subject of this study was to investigate whether TAMs are related to the chemotherapeutic response with triple-negative breast cancers (TNBC).

Methods: We retrospectively analyzed pretreatment tissue from patients who received NAC and followed by a mastectomy or breast-conservation for stage II-III TNBC in this study. The association between TAMs and the pathological complete response (pCR) rate of TNBC to NAC was analyzed. In addition, the correlation of the TAMs with recurrence-free survival (RFS) in patients with TNBC was also evaluated.

Results: Of the 91 patients, 31 (34.1%) patients experienced pathological complete response (pCR) after completion of NAC. Regarding the chemotheraptic response, patients with low infiltration of CD163⁺ macrophages achieved a significantly higher rate of pCR. Importantly, Kaplan-Meier survival shown that patients with high infiltration of CD163⁺ macrophages and non-pCR had poor OS and RFS.

Conclusions: our data showed that TAMs may predict chemotherapeutic response and can be used as a promising prognostic candidate for poor survival in TNBC patients treated with NAC.

Keywords: triple-negative breast cancer, tumor-associated macrophages, neoadjuvant chemotherapy, prognosis

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APA

Ye, J.h., Wang, X.h., Shi, J.j., Yin, X., Chen, C., Chen, Y., Wu, H.Y., Jiong, S., sun, Q., Zhang, M., Shi, X.b., Zhou, G.r., Hassan, S., Feng, J.f., Xu, X.y., Zhang, W.j. (2021). Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer. Journal of Cancer, 12(10), 2886-2892. https://doi.org/10.7150/jca.47566.

ACS

Ye, J.h.; Wang, X.h.; Shi, J.j.; Yin, X.; Chen, C.; Chen, Y.; Wu, H.Y.; Jiong, S.; sun, Q.; Zhang, M.; Shi, X.b.; Zhou, G.r.; Hassan, S.; Feng, J.f.; Xu, X.y.; Zhang, W.j. Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer. J. Cancer 2021, 12 (10), 2886-2892. DOI: 10.7150/jca.47566.

NLM

CSE

Ye Jh, Wang Xh, Shi Jj, Yin X, Chen C, Chen Y, Wu HY, Jiong S, sun Q, Zhang M, Shi Xb, Zhou Gr, Hassan S, Feng Jf, Xu Xy, Zhang Wj. 2021. Tumor-associated macrophages are associated with response to neoadjuvant chemotherapy and poor outcomes in patients with triple-negative breast cancer. J Cancer. 12(10):2886-2892.

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