ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma

Zhang, Chunyu; Wang, Long; Liu, Haitao; Deng, Gang; Xu, Pengfei; Tan, Yinqiu; Xu, Yang; Liu, Baohui; Chen, Qianxue; Tian, Daofeng

doi:10.7150/jca.51643

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Theranostics

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J Cancer 2021; 12(10):2912-2920. doi:10.7150/jca.51643 This issue Cite

Research Paper

ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma

Chunyu Zhang^1#, Long Wang^1#, Haitao Liu², Gang Deng¹, Pengfei Xu³, Yinqiu Tan¹, Yang Xu¹, Baohui Liu¹, Qianxue Chen¹, Daofeng Tian^1✉

1. Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, Hubei Province, P.R.C.
2. Department of Cardiothoracic Surgery, The First Affiliated Hospital of Jiaxing University, Jiaxing, 314001, Zhejiang Province, P.R.C.
3. Sun Yat-sen University, The Seventh Affiliated Hospital, Shenzhen, 518000, Guangdong Province, P.R.C.
#These authors contributed equally to this work.

Citation:

Zhang C, Wang L, Liu H, Deng G, Xu P, Tan Y, Xu Y, Liu B, Chen Q, Tian D. ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma. J Cancer 2021; 12(10):2912-2920. doi:10.7150/jca.51643. https://www.jcancer.org/v12p2912.htm

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Abstract

Background: ADPRH is a modulator of CD8+ T cell functions, and dysregulation of ADPRH has been identified to involve in carcinogenesis of cancers. However, the association of ADPRH with low grade glioma (LGG) remains unclear.

Methods: The expression of ADPRH in LGG was first analyzed in GLIOVIS and GEPIA databases and then validated by real-time PCR (rt-PCR), immunochemistry and human protein atlas (HPA). Univariate and multivariate Cox analysis and Kaplan-Meier plots were designed to assess the prognostic value of ADPRH in LGG. The correlation of ADPRH and immune infiltration was evaluated by data in TIMER and ESTIMATE databases. Gene set enrichment analysis was conducted to detect biological processes associated with ADPRH.

Results: ADPRH was significantly upregulated in LGG in comparison to non-tumor brain samples in transcriptomic and proteomic levels. The high ADPRH expression indicated unfavorable overall survival (OS) and progression-free survival (PFS) in patients with LGG using Kaplan-Meier plots. And multivariate Cox analysis demonstrated the expression level of ADPRH was an independent prognosis-predicting index for OS and PFS of LGG patients in all cohorts separately. Gene Set Enrichment Analysis (GSEA) indicated that high expression of ADPRH was involved in the upregulation of P53 signaling pathway, KRAS signaling pathway, IL6/JAK-STAT3 signaling and TNF-beta signaling pathways. By TIMER and ESTIMATE databases, we identified ADPRH expression had strong correlation with tumor immune infiltrating cells (TIICs).

Conclusions: In summary, our findings demonstrated that ADPRH might be a potential prognostic biomarker and correlated with TIICs in LGG.

Keywords: low grade glioma, immune infiltration, biomarker, TCGA, CGGA

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APA

Zhang, C., Wang, L., Liu, H., Deng, G., Xu, P., Tan, Y., Xu, Y., Liu, B., Chen, Q., Tian, D. (2021). ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma. Journal of Cancer, 12(10), 2912-2920. https://doi.org/10.7150/jca.51643.

ACS

Zhang, C.; Wang, L.; Liu, H.; Deng, G.; Xu, P.; Tan, Y.; Xu, Y.; Liu, B.; Chen, Q.; Tian, D. ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma. J. Cancer 2021, 12 (10), 2912-2920. DOI: 10.7150/jca.51643.

NLM

CSE

Zhang C, Wang L, Liu H, Deng G, Xu P, Tan Y, Xu Y, Liu B, Chen Q, Tian D. 2021. ADPRH is a prognosis-related biomarker and correlates with immune infiltrates in low grade glioma. J Cancer. 12(10):2912-2920.

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