ISSN: 1837-9664Journal of Cancer
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J Cancer 2021; 12(13):3809-3818. doi:10.7150/jca.54527 This issue Cite
Research Paper
YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A
Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China.
#These authors contributed equally to this work.
Citation:
Hong L, Pu X, Gan H, Weng l, Zheng Q. YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. J Cancer 2021; 12(13):3809-3818. doi:10.7150/jca.54527. https://www.jcancer.org/v12p3809.htm
Other stylesAbstract
RNA epigenetic modification take part in many biology processes, and the N6-methyladenosine (m6A) methylation of specific mRNAs in endometrial cancer (EC) tissues play a key role in regulating the tumorigenicity of EC, but the specific mechanism still unknown and need to be investigated in the future. Here, we found that m6A reader protein YTHDF2 expression was significantly upregulated in EC compare to tumor adjacent tissues, YTHDF2 was then identified to inhibit the proliferation and invasion of EC cell lines. Mechanistically, the m6A reader YTHDF2 bind the methylation sites of target transcripts IRS1 and promoted IRS1 mRNA degradation, consequently inhibiting the expression of IRS1 and inhibiting IRS1/AKT signaling pathway, finally inhibit the tumorigenicity of EC. Thus, we demonstrated that YTHDF2 inhibited the proliferation and invasion of EC via inhibiting IRS1 expression in m6A epigenetic way, which suggests a potential therapeutic target for EC.
Keywords: YTHDF2, IRS1, endometrial cancer, AKT signaling pathway, m6A modification
Citation styles
APA
Hong, L., Pu, X., Gan, H., Weng, l., Zheng, Q. (2021). YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. Journal of Cancer, 12(13), 3809-3818. https://doi.org/10.7150/jca.54527.
ACS
Hong, L.; Pu, X.; Gan, H.; Weng, l.; Zheng, Q. YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. J. Cancer 2021, 12 (13), 3809-3818. DOI: 10.7150/jca.54527.
NLM
Hong L, Pu X, Gan H, Weng l, Zheng Q. YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. J Cancer 2021; 12(13):3809-3818. doi:10.7150/jca.54527. https://www.jcancer.org/v12p3809.htm
CSE
Hong L, Pu X, Gan H, Weng l, Zheng Q. 2021. YTHDF2 inhibit the tumorigenicity of endometrial cancer via downregulating the expression of IRS1 methylated with m6A. J Cancer. 12(13):3809-3818.
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