J Cancer 2021; 12(15):4604-4615. doi:10.7150/jca.58640


Circular RNAs as novel potential biomarkers for pancreatic cancer

Shanshan Liu1, Qiuyue Li1, Yan Ma1, Christopher Corpe2, Jin Wang1✉

1. Shanghai Public Health Clinical Center, Fudan University, 2901 Caolang Road, Jinshan District, Shanghai 201508, China.
2. King's College London, London, Nutritional Science Department, 150 Stamford street, waterloo, London, SE19NH, United Kingdom.

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Liu S, Li Q, Ma Y, Corpe C, Wang J. Circular RNAs as novel potential biomarkers for pancreatic cancer. J Cancer 2021; 12(15):4604-4615. doi:10.7150/jca.58640. Available from https://www.jcancer.org/v12p4604.htm

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Pancreatic cancer (PaCa) is the fourth leading cause of cancer-related deaths in the United States, and the vast majority of these malignancies are pancreatic ductal adenocarcinomas (PDAC), but there is still a lack of early detection biomarkers for PaCa. Unlike linear RNAs, circRNAs form covalently closed continuous loops and can act as mammalian gene regulators. They may be diagnostic or predictive biomarkers for some tumors, also be novel potential therapeutic targets in different diseases. This review focuses on (1) the biogenesis of circRNAs, RNA binding proteins (RBPs) and complementary sequences of circRNAs; (2) the characteristics of circRNAs which allow them to interact with miRNAs; (3) the roles of circRNAs playing in the regulation of gene expression, cell behavior and cancer, and their potential role as novel biomarkers and therapeutic targets in pancreatic cancer.

Keywords: circRNAs, pancreatic cancer, biomarkers, diagnostics, therapy