1. Department of Respiratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 2. Department of rheumatism and immunology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 3. The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China. 4. Department of Respiratory Medicine, Zhengzhou Central Hospital, Zhengzhou 450052, China. #These authors contributed equally to this work.
Fan F, Yin R, Wang L, Zhao S, Lv D, Yang K, Geng S, Yang N, Zhang X, Wang H. ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. J Cancer 2021; 12(16):4780-4790. doi:10.7150/jca.58250. https://www.jcancer.org/v12p4780.htm
Lung adenocarcinoma (LUAD) is a lethal malignancy with metastasis, a major tumor feature that predominantly correlated with progression, but the molecules that mediated tumor metastasis remain elusive. To declare the critical regulatory genes, RNA sequencing data in LUAD patients was acquired from The Cancer Genome Atlas (TCGA) and found that ALDH3A1 was distinctly highly expressed in LUAD patients with metastasis (M1) compared with those without metastasis (M0), linked to the property of cancer stem cell and epithelial-mesenchymal transition (EMT). Besides, high ALDH3A1 expression predicted a poor prognosis. Knockdown of ALDH3A1 showed decreased proliferation, migration, and invasion in A549 cell line. Furthermore, BAG1 was regulated by ALDH3A1 through p53, enhanced cell proliferation, and predicted clinical prognosis. Our findings collectively uncovered a novel mechanism that orchestrates tumor cells' metastasis, and decreasing ALDH3A1 represented a potential therapeutic target for reprogramming metastasis.
Fan, F., Yin, R., Wang, L., Zhao, S., Lv, D., Yang, K., Geng, S., Yang, N., Zhang, X., Wang, H. (2021). ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. Journal of Cancer, 12(16), 4780-4790. https://doi.org/10.7150/jca.58250.
ACS
Fan, F.; Yin, R.; Wang, L.; Zhao, S.; Lv, D.; Yang, K.; Geng, S.; Yang, N.; Zhang, X.; Wang, H. ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. J. Cancer 2021, 12 (16), 4780-4790. DOI: 10.7150/jca.58250.
NLM
Fan F, Yin R, Wang L, Zhao S, Lv D, Yang K, Geng S, Yang N, Zhang X, Wang H. ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. J Cancer 2021; 12(16):4780-4790. doi:10.7150/jca.58250. https://www.jcancer.org/v12p4780.htm
CSE
Fan F, Yin R, Wang L, Zhao S, Lv D, Yang K, Geng S, Yang N, Zhang X, Wang H. 2021. ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. J Cancer. 12(16):4780-4790.
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