Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma

Wang, Yiwei; Xie, Xiaochen; Li, Shu; Zhang, Dongyong; Zheng, Heyu; Zhang, Min; Zhang, Zhong

doi:10.7150/jca.60596

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International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(19):5745-5752. doi:10.7150/jca.60596 This issue Cite

Research Paper

Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma

Yiwei Wang^1,2, Xiaochen Xie³, Shu Li¹, Dongyong Zhang⁴, Heyu Zheng¹, Min Zhang², Zhong Zhang^2✉

1. Department of Human Anatomy, Shenyang Medical College, Shenyang City, Liaoning Province 110034, P.R. China.
2. Department of Pathology, College of Basic Medical Sciences, Shenyang Medical College, Shenyang City, Liaoning Province 110034, P.R. China.
3. Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, 110001, P.R. China.
4. Department of Neurosurgery, First Affiliated Hospital of China Medical University, Heping District, Shenyang City, Liaoning Province, 110001, P.R. China

Citation:

Wang Y, Xie X, Li S, Zhang D, Zheng H, Zhang M, Zhang Z. Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma. J Cancer 2021; 12(19):5745-5752. doi:10.7150/jca.60596. https://www.jcancer.org/v12p5745.htm

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Abstract

Glioblastoma multiforme (GBM) is one of the most frequent primary malignancies of the brain. Although the treatment strategy has significantly improved, patient prognosis remains poor. In vitro studies have shown that the right open reading frame kinase 1/protein kinase B (RIOK1-AKT) signaling pathway plays an important role in the malignant phenotype of glioma cells. This study aimed to investigate the co-expression of RIOK1 and ATK in glioma tissues and its clinical significance. Compared with normal tissues, RIOK1 and AKT1 expression were significantly upregulated in glioma tissues. In addition, patients with higher World Health Organization staging grades had increased RIOK1 and AKT1 expression levels, and RIOK1 and AKT1 expression were positively correlated. Notably, both RIOK1 and AKT1 expressions were correlated with poor prognosis. In vitro experiments showed that silencing RIOK1 inhibited the proliferation, migration, and invasion of glioma cell lines by suppressing AKT and c-Myc expression. These results indicate that the RIOK1-AKT1 axis could play an important role in GBM progression.

Keywords: RIOK1, AKT1, c-Myc, GBM

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APA

Wang, Y., Xie, X., Li, S., Zhang, D., Zheng, H., Zhang, M., Zhang, Z. (2021). Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma. Journal of Cancer, 12(19), 5745-5752. https://doi.org/10.7150/jca.60596.

ACS

Wang, Y.; Xie, X.; Li, S.; Zhang, D.; Zheng, H.; Zhang, M.; Zhang, Z. Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma. J. Cancer 2021, 12 (19), 5745-5752. DOI: 10.7150/jca.60596.

NLM

CSE

Wang Y, Xie X, Li S, Zhang D, Zheng H, Zhang M, Zhang Z. 2021. Co-overexpression of RIOK1 and AKT1 as a prognostic risk factor in glioma. J Cancer. 12(19):5745-5752.

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