J Cancer 2021; 12(19):5895-5902. doi:10.7150/jca.60893 This issue Cite

Review

Effects of biomechanical forces on the biological behavior of cancer stem cells

Bo Ren Tian, Wei Fan Lin, Yan Zhang

MOE Key Laboratory of Gene Function and Regulation, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, Guangdong, People's Republic of China.

Citation:
Tian BR, Lin WF, Zhang Y. Effects of biomechanical forces on the biological behavior of cancer stem cells. J Cancer 2021; 12(19):5895-5902. doi:10.7150/jca.60893. https://www.jcancer.org/v12p5895.htm
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Abstract

Graphic abstract

Cancer stem cells (CSCs), dynamic subsets of cancer cells, are responsible for malignant progression. The unique properties of CSCs, including self-renewal, differentiation, and malignancy, closely depend on the tumor microenvironment. Mechanical components in the microenvironment, including matrix stiffness, fluid shear stress, compression and tension stress, affect the fate of CSCs and further influence the cancer process. This paper reviews recent studies of mechanical components and CSCs, and further discusses the intrinsic correlation among them. Regulatory mechanisms of mechanical microenvironment, which act on CSCs, have great potential for clinical application and provide different perspectives to drugs and treatment design.

Keywords: tumor microenvironment, cancer stem cell, matrix stiffness, shear stress, compression and tension


Citation styles

APA
Tian, B.R., Lin, W.F., Zhang, Y. (2021). Effects of biomechanical forces on the biological behavior of cancer stem cells. Journal of Cancer, 12(19), 5895-5902. https://doi.org/10.7150/jca.60893.

ACS
Tian, B.R.; Lin, W.F.; Zhang, Y. Effects of biomechanical forces on the biological behavior of cancer stem cells. J. Cancer 2021, 12 (19), 5895-5902. DOI: 10.7150/jca.60893.

NLM
Tian BR, Lin WF, Zhang Y. Effects of biomechanical forces on the biological behavior of cancer stem cells. J Cancer 2021; 12(19):5895-5902. doi:10.7150/jca.60893. https://www.jcancer.org/v12p5895.htm

CSE
Tian BR, Lin WF, Zhang Y. 2021. Effects of biomechanical forces on the biological behavior of cancer stem cells. J Cancer. 12(19):5895-5902.

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