Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer

Tang, Ying; Hu, Hui-quan; Tang, Ya-lan; Tang, Fang-xiang; Zheng, Xue-mei; Deng, Li-hong; Yang, Ming-tao; Yin, Su; Li, Jun; Xu, Fan

doi:10.7150/jca.62090

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2021; 12(19):5923-5928. doi:10.7150/jca.62090 This issue Cite

Research Paper

Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer

Ying Tang^1#, Hui-quan Hu^1#, Ya-lan Tang^1#, Fang-xiang Tang², Xue-mei Zheng², Li-hong Deng², Ming-tao Yang¹, Su Yin¹, Jun Li¹, Fan Xu^1✉

1. Department of Obstetrics and Gynecology, The Affiliated Nanchong Central Hospital of North Sichuan Medical College, Nanchong, Sichuan, China.
2. North Sichuan Medical College, Nanchong, Sichuan, China.
#These authors contributed equally to this work.

Citation:

Tang Y, Hu Hq, Tang Yl, Tang Fx, Zheng Xm, Deng Lh, Yang Mt, Yin S, Li J, Xu F. Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer. J Cancer 2021; 12(19):5923-5928. doi:10.7150/jca.62090. https://www.jcancer.org/v12p5923.htm

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Abstract

Objectives: This study was to analyze the relationships between lymphocyte-to-monocyte ratio (LMR) alone or combined with serum CA125 (COLC) and advanced stage of ovarian cancer (OC).

Methods: The receiver-operating characteristic (ROC) curves of LMR, CA125, and COLC staging OC were constructed by a retrospective study. Furthermore, a binary logistic regression model was used to assay the independent risk factors for OC staging.

Results: Two hundred and twenty-five patients with OC were identified in this cohort. Eighty-five OC patients were diagnosed at an early stage, and 140 OC patients were diagnosed at an advanced stage. The median of LMR in the early stage was higher than that in advanced stage (4.4 vs. 2.8), and the median of serum CA125 was lower than that in advanced stage (80 U/mL vs. 251.3 U/mL). Multivariate logistic regression LMR≤3.7 (OR=0.299, 95% CI: 0.093-0.962, P=0.043) and CA125>95.7 U/mL (OR=4.317, 95% CI: 1.436-12.977, P=0.009) were risk factors for stage of advanced OC whether presence or absence of malignant ascites. Furthermore, the area under the curve of COLC was higher than that of LMR (0.782 vs. 0.732) or serum CA125 (0.782 vs. 0.708) in staging OC. The specificity of COLC was higher than that of LMR (87.1% vs. 70.6%) or serum CA125 (87.1% vs. 61.2%) in staging OC.

Conclusion: LMR alone or in combination with serum CA125 might be associated with OC staging. Besides, as a predictive factor, COLC may have a high specificity in staging OC.

Keywords: Ovarian cancer, lymphocyte-to-monocyte ratio (LMR), CA125, International Federation of Gynecology and Obstetrics (FIGO), stage, combine

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APA

Tang, Y., Hu, H.q., Tang, Y.l., Tang, F.x., Zheng, X.m., Deng, L.h., Yang, M.t., Yin, S., Li, J., Xu, F. (2021). Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer. Journal of Cancer, 12(19), 5923-5928. https://doi.org/10.7150/jca.62090.

ACS

Tang, Y.; Hu, H.q.; Tang, Y.l.; Tang, F.x.; Zheng, X.m.; Deng, L.h.; Yang, M.t.; Yin, S.; Li, J.; Xu, F. Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer. J. Cancer 2021, 12 (19), 5923-5928. DOI: 10.7150/jca.62090.

NLM

CSE

Tang Y, Hu Hq, Tang Yl, Tang Fx, Zheng Xm, Deng Lh, Yang Mt, Yin S, Li J, Xu F. 2021. Preoperative LMR and Serum CA125 Level as Risk Factors for Advanced Stage of Ovarian Cancer. J Cancer. 12(19):5923-5928.

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