J Cancer 2021; 12(20):6012-6020. doi:10.7150/jca.51627 This issue

Review

Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases

Xuelian Zhang1,2,3,4#, Bin Zhang1,2,3,4#, Chenyang Zhang1,2,3,4, Guibo Sun1,2,3,4✉, Xiaobo Sun1,2,3,4✉

1. Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China.
2. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing 100193, China.
3. Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing 100193, China.
4. Key Laboratory of efficacy evaluation of Chinese Medicine against Glyeolipid Metabolism Disorder Disease, State Administration of Traditional Chinese Medicine, Beijing 100193, China.
#These authors contributed equally to this work.

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Citation:
Zhang X, Zhang B, Zhang C, Sun G, Sun X. Current Progress in Delineating the Roles of Pseudokinase TRIB1 in Controlling Human Diseases. J Cancer 2021; 12(20):6012-6020. doi:10.7150/jca.51627. Available from https://www.jcancer.org/v12p6012.htm

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Abstract

Graphic abstract

Tribbles homolog 1 (TRIB1) is a member of the tribbles family of pseudoprotein kinases and is widely expressed in numerous tissues, such as bone marrow, skeletal muscle, liver, heart, and adipose tissue. It is closely associated with acute myeloid leukemia, prostate cancer, and tumor drug resistance, and can interfere with the hematopoietic stem cell cycle, promote tumor cell proliferation, and inhibit apoptosis. Recent studies have shown that TRIB1 can regulate acute and chronic inflammation by affecting the secretion of inflammatory factors, which is closely related to the occurrence of hyperlipidemia and cardiovascular diseases. Given the important biological functions of TRIB1, the reviews published till now are not sufficiently comprehensive. Therefore, this paper reviews the progress in TRIB1 research aimed at exploring its roles in cancer, hyperlipidemia, and cardiovascular disease, and providing a theoretical basis for further studies on the biological roles of TRIB1.

Keywords: TRIB1, pseudokinase family, acute myeloid leukemia, prostate cancer, tumor drug resistance, cardiovascular disease