J Cancer 2021; 12(20):6094-6104. doi:10.7150/jca.56098 This issue

Research Paper

miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway

Xinxin Zhang1, Yi Zhang1, Lei Dou1✉

1. Department of Discipline Inspection Commission, China Medical University, Shenyang 110001, Liaoning, China.
2. Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning, China.

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Citation:
Zhang X, Zhang Y, Dou L. miR-552 promotes the proliferation and metastasis of cervical cancer cells through targeting MUC15 pathway. J Cancer 2021; 12(20):6094-6104. doi:10.7150/jca.56098. Available from https://www.jcancer.org/v12p6094.htm

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Abstract

Graphic abstract

Accumulating evidence shows that microRNAs (miRNAs) play key roles in tumorigenesis, progression, recurrence and drug resistance of malignant tumors. The tumor-promoting role of miR-552 has been evidenced in multiple tumors. Yet, the relevance of miR-552 in cervical cancer remains undetermined. This study aimed to investigate the role of miR-552 in cervical cancer proliferation and metastasis. Herein, we for first found that miR-552 expression was upregulated in cervical cancer tissues compared with their normal controls. Functional assays revealed that miR-552 promoted the proliferation and metastasis of cervical cancer cells. Mechanically, bioinformatics and luciferase reporter analysis identified MUC15 as a direct target of miR-552. Reduced MUC15 expression was detected in cervical cancer, and MUC15 overexpression exhibited a tumor-suppressive effect. MUC15 restoration partially abolished the discrepancy of growth and metastasis capacity between miR-552 overexpression cervical cancer cells and control cells. Taken together, these data demonstrate that miR-552 acts as a potential oncogene miRNA in cervical cancer, which exerts its function through targeting MUC15.

Keywords: cervical cancer, miR-552, MUC15, proliferation, metastasis