The regulatory networks of the Hippo signaling pathway in cancer development

Maonan Wang^1,2, Manli Dai³, Dan Wang^1,2, Wei Xiong^1,2, Zhaoyang Zeng^1,2✉, Can Guo^1,2✉

1. NHC Key Laboratory of Carcinogenesis, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
2. Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.
3. Hunan Food and Drug Vocational College, Changsha 410036, China.

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Citation:
Wang M, Dai M, Wang D, Xiong W, Zeng Z, Guo C. The regulatory networks of the Hippo signaling pathway in cancer development. J Cancer 2021; 12(20):6216-6230. doi:10.7150/jca.62402. Available from https://www.jcancer.org/v12p6216.htm

Abstract

The Hippo signaling pathway is a relatively young tumor-related signaling pathway. Although it was discovered lately, research on it developed rapidly. The Hippo signaling pathway is closely relevant to the occurrence and development of tumors and the maintenance of organ size and other biological processes. This manuscript focuses on YAP, the core molecule of the Hippo signaling pathway, and discussion the upstream and downstream regulatory networks of the Hippo signaling pathway during tumorigenesis and development. It also summarizes the relevant drugs involved in this signaling pathway, which may be helpful to the development of targeted drugs for cancer therapy.

Keywords: Hippo signaling pathway, YAP, Tumor development