J Cancer 2022; 13(1):313-324. doi:10.7150/jca.64846 This issue Cite

Review

A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis

Qian Yi1,2,4#, Wei Xie3#, Wei Sun3✉, Weichao Sun1,3✉, Yi Liao1✉

1. The Central Laboratory, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong 518035, P.R. China.
2. Department of Physiology, School of Basic Medical Science, Southwest Medical University, Luzhou, Sichuan province 646099, P.R. China.
3. Department of Orthopedics, Shenzhen Second People's Hospital/First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong 518035, P.R. China.
4. Laboratory of Anesthesia and Organ Protection, Southwest Medical University, Luzhou, Sichuan province 646099, P.R. China.
#. Q.Y. and W.X. contributed equally to this review.

Citation:
Yi Q, Xie W, Sun W, Sun W, Liao Y. A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis. J Cancer 2022; 13(1):313-324. doi:10.7150/jca.64846. https://www.jcancer.org/v13p0313.htm
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Abstract

Graphic abstract

MicroRNAs (miRNAs) are small noncoding RNAs that commonly have 18-22 nucleotides and play important roles in the regulation of gene expression via directly binding to the 3'-UTR of target mRNAs. Approximately 50% of human genes are regulated by miRNAs and they are involved in many human diseases, including various types of cancers. Recently, microRNA-383 (miR-383) has been identified as being aberrantly expressed in multiple cancers, such as malignant melanoma, colorectal cancer, hepatocellular cancer, and glioma. Increasing evidence suggests that miR-383 participates in tumorigenic events including proliferation, apoptosis, invasion, and metastasis as well as drug resistance. Although downstream targets including CCND1, LDHA, VEGF, and IGF are illustrated to be regulated by miR-383, its roles in carcinogenesis are still ambiguous and the underlying mechanisms are still unclear. Herein, we review the latest studies on miR-383 and summarize its functions in human cancers and other diseases. The goal of this review is to provide new strategies for targeted therapy and further investigations.

Keywords: miR-383, Cancer, Proliferation, Apoptosis, Invasion, Metastasis


Citation styles

APA
Yi, Q., Xie, W., Sun, W., Sun, W., Liao, Y. (2022). A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis. Journal of Cancer, 13(1), 313-324. https://doi.org/10.7150/jca.64846.

ACS
Yi, Q.; Xie, W.; Sun, W.; Sun, W.; Liao, Y. A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis. J. Cancer 2022, 13 (1), 313-324. DOI: 10.7150/jca.64846.

NLM
Yi Q, Xie W, Sun W, Sun W, Liao Y. A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis. J Cancer 2022; 13(1):313-324. doi:10.7150/jca.64846. https://www.jcancer.org/v13p0313.htm

CSE
Yi Q, Xie W, Sun W, Sun W, Liao Y. 2022. A Concise Review of MicroRNA-383: Exploring the Insights of Its Function in Tumorigenesis. J Cancer. 13(1):313-324.

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