J Cancer 2022; 13(2):691-705. doi:10.7150/jca.62683 This issue

Review

Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell Carcinoma

Huijie Zhang1#, Lei Yu2#, Jing Chen3#, Liting Liu1, Xudong Yang4, Hongwei Cui1✉, Genquan Yue4✉

1. Clinical research center, The Affiliated Hospital of Inner Mongolia Medical University/Key Laboratory of Medical Cell Biology of Inner Mongolia Autonomous Region, Hohhot 010050, China.
2. Department of Pharmacy, Traditional Chinese Medicine Hospital of Inner Mongolia Autonomous Region, Hohhot 010020, China.
3. Department of Medicine, Ordos Institute of Technology,Inner Mongolia Autonomous Region, Ordos 017000, China.
4. Department of Urology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China.
# These authors are equal contributors for this review.

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Citation:
Zhang H, Yu L, Chen J, Liu L, Yang X, Cui H, Yue G. Role of Metabolic Reprogramming of Long non-coding RNA in Clear Cell Renal Cell Carcinoma. J Cancer 2022; 13(2):691-705. doi:10.7150/jca.62683. Available from https://www.jcancer.org/v13p0691.htm

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Abstract

Graphic abstract

Renal cell carcinoma (RCC), one of the most frequent cancers, is a "classical" malignancy characterized by metabolic reprogramming. Clear cell renal cell carcinoma (ccRCC) is its most common histopathological subtype. Long-stranded non-coding ribonucleic acids (LncRNAs) are regulatory RNA molecules with limited protein-coding capacity and evolutionary conservation. Recent studies have revealed that lncRNAs can broadly regulate the metabolic reprogramming of ccRCC and its malignant transformation. However, there are few studies on lncRNAs regulating the metabolism of ccRCC, and the specific mechanisms are unknown. Therefore, this paper summarizes the regulatory mechanisms of lncRNAs in the metabolism of ccRCC, especially in the pathways of glycolysis, mitochondrial function, glutamine and lipid metabolism, cellular mechanisms, interactions with other molecules, specific scientific and clinic implications and applications to provide a basis for early clinical diagnosis, prediction and treatment. We also discuss the clinical application and challenges of targeting lncRNAs in ccRCC metabolism.

Keywords: renal clear cell carcinoma, LncRNAs, metabolic reprogramming