J Cancer 2022; 13(3):943-950. doi:10.7150/jca.66959 This issue Cite

Research Paper

MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2

Yue Sun1,2, Chao Meng1,2, Guoyan Liu1,2✉

1. Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, 300052, China.
2. Tianjin Key Laboratory of Female Reproductive Health and Eugenics, Tianjin, 300052, China.

Citation:
Sun Y, Meng C, Liu G. MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. J Cancer 2022; 13(3):943-950. doi:10.7150/jca.66959. https://www.jcancer.org/v13p0943.htm
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Abstract

Graphic abstract

Objective: To investigate the role of miR-506-3p in ovarian cancer (OvCa) metastasis.

Methods: We overexpressed miR-506-3p in OvCa cells, and cell migration and invasion capacities were assessed in vitro using Transwell assays and wound healing assay. EZH2 is a target of miR-506-3p. We overexpressed and knocked down EZH2 in SKOV3 cells, and assessed its impact on cell migration and invasion. The orthotopic OvCa mouse models were conducted to confirm the role of miR-506-3p in OvCa metastasis.

Results: In this research, we found that miR-506-3p reduced EZH2 expression and obviously suppressed the cell migration and invasion in ovarian cancer (OvCa). Moreover, the knockout of EZH2 mimicked the effect of miR-506-3p on invasion and migration, whereas EZH2 overexpression rescued the inhibitory effect of miR-506-3p. The orthotopic OvCa mouse models and clinical cases also confirmed the negative correlation between miR-506-3p and EZH2 in OvCa

Conclusions: MiR-506-3p can suppress cell migration and invasion by targeting EZH2 in OvCa. Our study provides evidence supporting miR-506-3p-based therapy in OvCa.

Keywords: miR-506-3p, EZH2, ovarian cancer, metastasis


Citation styles

APA
Sun, Y., Meng, C., Liu, G. (2022). MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. Journal of Cancer, 13(3), 943-950. https://doi.org/10.7150/jca.66959.

ACS
Sun, Y.; Meng, C.; Liu, G. MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. J. Cancer 2022, 13 (3), 943-950. DOI: 10.7150/jca.66959.

NLM
Sun Y, Meng C, Liu G. MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. J Cancer 2022; 13(3):943-950. doi:10.7150/jca.66959. https://www.jcancer.org/v13p0943.htm

CSE
Sun Y, Meng C, Liu G. 2022. MicroRNA-506-3p inhibits ovarian cancer metastasis by down-regulating the expression of EZH2. J Cancer. 13(3):943-950.

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