J Cancer 2022; 13(5):1480-1489. doi:10.7150/jca.65074 This issue

Review

Combinations of radiotherapy with immunotherapy in cervical cancer

Xiaojing Yang1*, Hanru Ren2*, Jie Fu1✉

1. Department of Radiation Oncology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, No. 600, Yishan Road, Shanghai, 200233, China.
2. Department of Orthopedics, Shanghai Pudong Hospital, Fudan University, Pudong Medical Center, Shanghai 201300, P.R China.
*These authors contributed equally to this work.

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Citation:
Yang X, Ren H, Fu J. Combinations of radiotherapy with immunotherapy in cervical cancer. J Cancer 2022; 13(5):1480-1489. doi:10.7150/jca.65074. Available from https://www.jcancer.org/v13p1480.htm

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Abstract

Graphic abstract

Immunotherapy serves as another effective cancer treatment apart from surgery, chemoradiotherapy, and targeted drug therapy. Radiotherapy combined with immunotherapy has significantly improved the effective cure rate for patients in several clinical trials. It subverted the traditional view that radiotherapy kills immune cells and has immunosuppressive effects, indicating a synergistic effect of radiotherapy and immunotherapy. In this article, we reviewed and summarized the molecular mechanism of the combined use of radiotherapy and immunotherapy, as well as the clinical treatment and safety of the combination of the two. We describe the rationale for the integration of radiotherapy and immunotherapy in patients with cervical cancer, present safety and efficacy data that support this combination strategy, and highlight unanswered question sand future research needs. Besides, this study can be referenced for clinicians to guide subsequent clinical medicine.

Keywords: Immunotherapy, Radiotherapy, cervical cancer