J Cancer 2022; 13(6):1713-1724. doi:10.7150/jca.70550 This issue

Review

Cytokeratin Expression Pattern in Human Endometrial Carcinomas and Lymph Nodes Micrometastasis: a Mini-review

Danuta Vasilevska1, Vilius Rudaitis2, Aneta Adamiak-Godlewska3, Anna Semczuk-Sikora4, Dorota Lewkowicz5, Dominika Vasilevska2, Andrzej Semczuk3✉

1. Vilnius University Hospital “Santaros Clinics”, Department of Gynecology, Vilnius, Lithuania
2. Faculty of Medicine, Vilnius University, Vilnius, Lithuania
3. IIND Department of Gynecology, Lublin Medical University, Lublin, Poland
4. Department of Pathology of Pregnancy, Lublin Medical University, Lublin, Poland
5. Department of Clinical Pathology, Lublin Medical University, Lublin, Poland

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Citation:
Vasilevska D, Rudaitis V, Adamiak-Godlewska A, Semczuk-Sikora A, Lewkowicz D, Vasilevska D, Semczuk A. Cytokeratin Expression Pattern in Human Endometrial Carcinomas and Lymph Nodes Micrometastasis: a Mini-review. J Cancer 2022; 13(6):1713-1724. doi:10.7150/jca.70550. Available from https://www.jcancer.org/v13p1713.htm

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Abstract

Graphic abstract

Cytokeratins (CKs) are the largest subgroup of intermediate filament proteins, preferentially expressed in epithelial tissues. CKs play a critical role in determining epithelial structural integrity under stressful conditions in addition to their various fundamental functions in cellular proliferation, apoptosis, migration, adherence and molecular signaling. Immunohistochemical CKs staining could be evaluated with a proper comprehension of their task limitations and their association with the normal morphology to avoid misdiagnosis. Herein, we critically review the CKs expression patterns in ECs in relation to clinicopathological features and patients' outcome. We also briefly discussed the recent advantage of CKs immunohistochemical staining in the detection of EC micrometastasis.

Keywords: Cytokeratin, Endometrial Carcinomas, Lymph Node, Metastasis, OSNA.