The Role of CTNNA1 in Malignancies: An Updated Review

Huang, Jinhua; Wang, Huihui; Xu, Yuting; Li, Chunhua; Lv, Xinyue; Han, Xintong; Chen, Xiaochun; Chen, Yu; Yu, Zhiying

doi:10.7150/jca.79236

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Journal of Genomics

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J Cancer 2023; 14(2):219-230. doi:10.7150/jca.79236 This issue Cite

Review

The Role of CTNNA1 in Malignancies: An Updated Review

Jinhua Huang^1,2#, Huihui Wang^3#, Yuting Xu^1,2#, Chunhua Li¹, Xinyue Lv¹, Xintong Han¹, Xiaochun Chen¹, Yu Chen¹, Zhiying Yu^1✉

1. Department of Gynecology, Shenzhen Second People's Hospital/the First Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, 518035, Guangdong, China.
2. College of Medicine, Shantou University, Shantou, 515041, Guangdong, China.
3. Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Hefei, 230023, China.
#These authors contributed equally to this work.

Citation:

Huang J, Wang H, Xu Y, Li C, Lv X, Han X, Chen X, Chen Y, Yu Z. The Role of CTNNA1 in Malignancies: An Updated Review. J Cancer 2023; 14(2):219-230. doi:10.7150/jca.79236. https://www.jcancer.org/v14p0219.htm

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Abstract

Catenin alpha 1 (CTNNA1), encoding α-catenin, is involved in several physiological activities, such as adherens junction synthesis and signal transduction. Recent studies have suggested additional functions for CTNNA1 malignancies. This review systematically summarizes the varying functions of CTNNA1 in different tumors and briefly describes the diverse pathways and mechanisms involved in different types of tumors. CTNNA1 is abnormally expressed in leukemia and solid tumor such as cancers of digestive system, genitourinary system and breast, and it's related to the occurrence, development, and prognosis of tumors. In addition, the possible physiological processes involving CTNNA1, such as methylation, miRNA interference, or regulatory axes, similar to those of CDH1, SETD2, and hsa-miR-30d-5p/GJA1 are also summarized here. The precise mechanism of CTNNA1 in most cancers remains uncertain; hence, additional pre-clinical studies of CTNNA1 are warranted for potential early tumor diagnosis, prognosis, and treatment.

Keywords: α-catenin, CTNNA1, tumorigenesis

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APA

Huang, J., Wang, H., Xu, Y., Li, C., Lv, X., Han, X., Chen, X., Chen, Y., Yu, Z. (2023). The Role of CTNNA1 in Malignancies: An Updated Review. Journal of Cancer, 14(2), 219-230. https://doi.org/10.7150/jca.79236.

ACS

Huang, J.; Wang, H.; Xu, Y.; Li, C.; Lv, X.; Han, X.; Chen, X.; Chen, Y.; Yu, Z. The Role of CTNNA1 in Malignancies: An Updated Review. J. Cancer 2023, 14 (2), 219-230. DOI: 10.7150/jca.79236.

NLM

CSE

Huang J, Wang H, Xu Y, Li C, Lv X, Han X, Chen X, Chen Y, Yu Z. 2023. The Role of CTNNA1 in Malignancies: An Updated Review. J Cancer. 14(2):219-230.

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