J Cancer 2023; 14(2):275-280. doi:10.7150/jca.79171 This issue Cite

Review

The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review

Cen-Cen Sun1#, Li Li2,3#, Zhi-Chen jiang2, Zheng-Chuang Liu2,3, Liang Wang4✉, Hui-Ju Wang2,3✉

1. Basic Medical Experimental Teaching Center, Zhejiang University, Hangzhou 310030, Zhejiang, China.
2. Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
3. Cancer Center, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
4. Center for Plastic and Reconstructive Surgery, Department of Hand and Reconstruction Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.
#These authors contributed equally to this work.

Citation:
Sun CC, Li L, jiang ZC, Liu ZC, Wang L, Wang HJ. The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review. J Cancer 2023; 14(2):275-280. doi:10.7150/jca.79171. https://www.jcancer.org/v14p0275.htm
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Abstract

Graphic abstract

Pancreatic cancer (PaC) is a common malignant tumor of the digestive tract, with a 5-year survival rate of less than 5% and high mortality rate in the world. LncRNAs have been showed to possess multiple biological functions in growth, differentiation, and proliferation, which play an important role in different biological processes and diseases, especially in the development of tumors. LncRNA UCA1, which is firstly identified in human bladder cancer, has been showed to be a tumor promoter in pancreatic cancer. Recent researches have showed that UCA1 might promote pancreatic carcinogenesis and progression, and correlate with drug resistance. In this review, we address the biological function and regulatory mechanism of UCA1 in pancreatic cancer, which might give a new approach for clinical diagnosis and treatment.

Keywords: Pancreatic cancer, LncRNA UCA1, Carcinogenesis, Tumor progression, Drug resistance


Citation styles

APA
Sun, C.C., Li, L., jiang, Z.C., Liu, Z.C., Wang, L., Wang, H.J. (2023). The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review. Journal of Cancer, 14(2), 275-280. https://doi.org/10.7150/jca.79171.

ACS
Sun, C.C.; Li, L.; jiang, Z.C.; Liu, Z.C.; Wang, L.; Wang, H.J. The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review. J. Cancer 2023, 14 (2), 275-280. DOI: 10.7150/jca.79171.

NLM
Sun CC, Li L, jiang ZC, Liu ZC, Wang L, Wang HJ. The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review. J Cancer 2023; 14(2):275-280. doi:10.7150/jca.79171. https://www.jcancer.org/v14p0275.htm

CSE
Sun CC, Li L, jiang ZC, Liu ZC, Wang L, Wang HJ. 2023. The Functional Role of LncRNA UCA1 in Pancreatic Cancer: a mini-review. J Cancer. 14(2):275-280.

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