Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential

Lin, Hongze; Li, Jiaying; Wang, Maoye; Zhang, Xu; Zhu, Taofeng

doi:10.7150/jca.84506

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2023; 14(10):1736-1750. doi:10.7150/jca.84506 This issue Cite

Review

Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential

Hongze Lin¹, Jiaying Li¹, Maoye Wang², Xu Zhang³, Taofeng Zhu^1✉

1. Department of Pulmonary and Critical Care Medicine, Yixing Hospital affiliated to Jiangsu University, Yixing 214200, China.
2. School of Medicine, Jiangsu University, Zhenjiang 212013, China.
3. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.

Citation:

Lin H, Li J, Wang M, Zhang X, Zhu T. Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential. J Cancer 2023; 14(10):1736-1750. doi:10.7150/jca.84506. https://www.jcancer.org/v14p1736.htm

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Abstract

Exosomes are a typical subset of extracellular vesicles (EVs) that can be transmitted from parent cells to recipient cells via human bodily fluids. Exosomes perform a vital role in mediating intercellular communication by shuttling bioactive cargos, such as nucleic acids, proteins and lipids. Long noncoding RNAs (lncRNAs) are transcripts longer than 200 nucleotides without protein translation ability and can be selectively packaged into exosomes. Accumulating evidence indicates that exosomal lncRNAs have a critical role in tumor initiation and progression through regulating tumor proliferation, apoptosis, invasion, metastasis, angiogenesis, treatment resistance and tumor microenvironment. Increasing studies suggest that exosomal lncRNAs have great potential to be served as novel targets and non-invasive biomarkers for diagnosis and prognosis in non-small cell lung cancer (NSCLC). In this review, we provide an overview of current research on the disordered functions of exosomal lncRNAs in NSCLC and summarize their potential clinical applications as diagnostic and prognostic biomarkers and therapeutic targets for NSCLC.

Keywords: exosome, lncRNA, NSCLC, biomarker, target

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APA

Lin, H., Li, J., Wang, M., Zhang, X., Zhu, T. (2023). Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential. Journal of Cancer, 14(10), 1736-1750. https://doi.org/10.7150/jca.84506.

ACS

Lin, H.; Li, J.; Wang, M.; Zhang, X.; Zhu, T. Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential. J. Cancer 2023, 14 (10), 1736-1750. DOI: 10.7150/jca.84506.

NLM

CSE

Lin H, Li J, Wang M, Zhang X, Zhu T. 2023. Exosomal Long Noncoding RNAs in NSCLC: Dysfunctions and Clinical Potential. J Cancer. 14(10):1736-1750.

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