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J Cancer 2023; 14(11):2027-2038. doi:10.7150/jca.85011 This issue Cite

Research Paper

Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells

Ming Li1,2#, Qin Zhao1,2#, Jinzhuang Liao3#, Xiaocong Wang1,2, Lulu Liu1,2, Xiaoyue Zhang1,2, Lijun Liu4, Haidan Liu4✉, Shusheng Zhang1,2✉

1. Changsha Stomatological Hospital, Changsha, Hunan 410004, China.
2. School of Stomatology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.
3. Department of Radiology, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, China.
4. Clinical Center for Gene Diagnosis and Therapy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
# Ming Li, Qin Zhao, and Jinzhuang Liao contributed equally to this work.

✉ Corresponding authors: Dr. Haidan Liu, Clinical Center for Gene Diagnosis and Therapy, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China, E-mail: haidanliuedu.cn; Dr. Shusheng Zhang, School of Stomatology, H More

Citation:
Li M, Zhao Q, Liao J, Wang X, Liu L, Zhang X, Liu L, Liu H, Zhang S. Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. J Cancer 2023; 14(11):2027-2038. doi:10.7150/jca.85011. https://www.jcancer.org/v14p2027.htm
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Abstract

Graphic abstract

Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies, including oral squamous cell carcinoma (OSCC). Thus, survivin has been proposed as an attractive target for new antitumor interventions. In the present study, we found that a natural compound, Dioscin, inhibited OSCC cells by reducing the survivin protein level and activating apoptotic signaling. Dioscin inhibits survivin expression by interrupting EGFR binding to the AT-rich sequences (ATRSs) at the survivin promoter, eventually promoting survivin-mediated cell apoptosis. The in vivo study showed that Dioscin suppressed the tumor development of SCC25 cells. Furthermore, the immunohistochemistry (IHC) results revealed that treated with Dioscin reduced the protein levels of EGFR and survivin in SCC25 xenograft tumors. Overall, our findings indicate that targeting the EGFR-survivin axis might be a promising OSCC treatment strategy.

Keywords: Dioscin, EGFR, survivin, oral squamous cell carcinoma, apoptosis

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APA
Li, M., Zhao, Q., Liao, J., Wang, X., Liu, L., Zhang, X., Liu, L., Liu, H., Zhang, S. (2023). Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. Journal of Cancer, 14(11), 2027-2038. https://doi.org/10.7150/jca.85011.

ACS
Li, M.; Zhao, Q.; Liao, J.; Wang, X.; Liu, L.; Zhang, X.; Liu, L.; Liu, H.; Zhang, S. Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. J. Cancer 2023, 14 (11), 2027-2038. DOI: 10.7150/jca.85011.

NLM
Li M, Zhao Q, Liao J, Wang X, Liu L, Zhang X, Liu L, Liu H, Zhang S. Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. J Cancer 2023; 14(11):2027-2038. doi:10.7150/jca.85011. https://www.jcancer.org/v14p2027.htm

CSE
Li M, Zhao Q, Liao J, Wang X, Liu L, Zhang X, Liu L, Liu H, Zhang S. 2023. Dioscin inhibiting EGFR-mediated Survivin expression promotes apoptosis in oral squamous cell carcinoma cells. J Cancer. 14(11):2027-2038.

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