1. Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China. 2. Department of Thoracic Surgery, Ezhou Central Hospital, Ezhou, China. # These authors contributed equally to this work.
✉ Corresponding authors: Qing Geng, MD, Department of Thoracic Surgery, Renmin Hospital of Wuhan University, No.238 Jiefang Road, Wuchang District, Wuhan 430060, China; Telephone number: +86-27-8804-1919; Fax number: +86-27-8807-2292; E-mail address: gengqingwhuedu.cn. Zhihong Zhao, Department of Thoracic Surgery, Ezhou Central Hospital, No.9 Wenxing Road, Echeng District, Ezhou 436000, China; Telephone number: +86-27-60660425; E-mail address: 546295164com.More
Citation:
Song C, Song Y, Wan X, Zhao Z, Geng Q. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J Cancer 2024; 15(1):218-231. doi:10.7150/jca.88777. https://www.jcancer.org/v15p0218.htm
Histone H3-H4 chaperone anti-silencing function 1 (ASF1) plays an important role in the polymerization, transport, and modification of histones. However, the significance of ASF1B in lung adenocarcinoma (LUAD) is largely overlooked. We investigated the aberrant expression of ASF1B in LUAD and its potential link to patient survival using multiple databases. ASF1B-overexpressing and knockdown cell lines were constructed to explore its effects on the biological behavior of lung cancer cells. ssGSEA, TMB, TIDE and IMvigor210 cohort were used to explore and validate the association of ASF1B to tumor immunity. Our data suggested that ASF1B was overexpressed in LUAD, and was associated with poor prognosis. ASF1B promoted the proliferation, migration, and invasion of lung cancer cells by regulating the phosphorylation of AKT in vitro. ASF1B was associated with tumor immunity. In summary, ASF1B may promote malignant behavior of LUAD cells, and its overexpression correlates with worse prognosis and better immunotherapy effect.
Song, C., Song, Y., Wan, X., Zhao, Z., Geng, Q. (2024). Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. Journal of Cancer, 15(1), 218-231. https://doi.org/10.7150/jca.88777.
ACS
Song, C.; Song, Y.; Wan, X.; Zhao, Z.; Geng, Q. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J. Cancer 2024, 15 (1), 218-231. DOI: 10.7150/jca.88777.
NLM
Song C, Song Y, Wan X, Zhao Z, Geng Q. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J Cancer 2024; 15(1):218-231. doi:10.7150/jca.88777. https://www.jcancer.org/v15p0218.htm
CSE
Song C, Song Y, Wan X, Zhao Z, Geng Q. 2024. Carcinogenic Role and Clinical Significance of Histone H3-H4 Chaperone Anti-silencing Function 1 B (ASF1B) in Lung Adenocarcinoma. J Cancer. 15(1):218-231.
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