<i>ALKBH1</i> rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children

Zhang, Xinxin; Zhou, Chunlei; Zhao, Yemu; Deng, Changmi; Wu, Haiyan; Zhuo, Zhenjian; He, Jing

doi:10.7150/jca.89271

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J Cancer 2024; 15(2):526-532. doi:10.7150/jca.89271 This issue Cite

Research Paper

ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children

Xinxin Zhang^1#, Chunlei Zhou^2#, Yemu Zhao^3#, Changmi Deng¹, Haiyan Wu², Zhenjian Zhuo^1,4✉, Jing He^1✉

1. Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
2. Department of Pathology, Children's Hospital of Nanjing Medical University, Nanjing 210008, Jiangsu, China.
3. Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China.
4. Laboratory Animal Center, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, Guangdong, China.
# These authors contributed equally to this work.

Citation:

Zhang X, Zhou C, Zhao Y, Deng C, Wu H, Zhuo Z, He J. ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children. J Cancer 2024; 15(2):526-532. doi:10.7150/jca.89271. https://www.jcancer.org/v15p0526.htm

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Abstract

Neuroblastoma is a highly malignant extracranial solid tumor in pediatrics. ALKBH1 as a recently discovered DNA N6-methyldeoxyadenosine (6mA) demethylase closely links to tumorigenesis. Whether the ALKBH1 polymorphism contributes to neuroblastoma risk remains unclear. In the present study, we genotyped the ALKBH1 single nucleotide polymorphisms (SNPs) in 402 neuroblastoma patients and 473 healthy controls by TaqMan assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were also calculated to evaluate the strength of the association. Our result exhibited that the rs2267755 C>T (CT vs. CC, adjusted OR=0.69, 95% CI=0.50-0.94, P=0.019) is significantly associated with reduced neuroblastoma risk. And its protective effect is particularly significant in children with tumors originating from the retroperitoneal. Combined genotype analysis revealed that carriers with 1-2 protective genotypes are more susceptible to neuroblastoma than those with 3-4 protective genotypes (adjusted OR=0.71, 95% CI=0.53-0.97, P=0.028). Moreover, the rs2267755 C>T is significantly associated with messenger RNA (mRNA) expression of ALKBH1 and three of its surrounding genes, including SNWQ, ADCK1, and RPL21P10. These results suggest that the rs2267755 C>T may be a genetic variant to reduce neuroblastoma risk.

Keywords: neuroblastoma, ALKBH1, polymorphism, susceptibility

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APA

Zhang, X., Zhou, C., Zhao, Y., Deng, C., Wu, H., Zhuo, Z., He, J. (2024). ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children. Journal of Cancer, 15(2), 526-532. https://doi.org/10.7150/jca.89271.

ACS

Zhang, X.; Zhou, C.; Zhao, Y.; Deng, C.; Wu, H.; Zhuo, Z.; He, J. ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children. J. Cancer 2024, 15 (2), 526-532. DOI: 10.7150/jca.89271.

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CSE

Zhang X, Zhou C, Zhao Y, Deng C, Wu H, Zhuo Z, He J. 2024. ALKBH1 rs2267755 C>T polymorphism decreases neuroblastoma risk in Chinese children. J Cancer. 15(2):526-532.

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