PDF

J Cancer 2024; 15(6):1498-1510. doi:10.7150/jca.91984 This issue Cite

Review

LncRNA-MUF: A Novel Oncogenic Star with Potential as a Biological Marker and Therapeutic Target for Gastrointestinal Malignancies

Yang Wang^1#, Jialing Wang^2#, Yihan Zhang³, Hongliang Luo² , Huazhao Yuan⁴

1. Department of Gastroenterology, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China.
2. Department of Gastrointestinal Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China.
3. Second School of Clinical Medicine, Jiangxi Medical College, Nanchang University, Nanchang 330008, Jiangxi, China.
4. Department of General Surgery, Jiujiang Hospital of Traditional Chinese Medicine, Jiujiang 332007, Jiangxi, China.
^#These authors contributed equally to this work.

✉ Corresponding authors: Hongliang Luo (ndefy13028edu.cn) and Huazhao Yuan (yuanhuazhao1036com).

Abstract

Gastrointestinal (GI) cancers pose a significant global health challenge, characterized by a high incidence and poor prognosis. The delayed detection and occurrence of metastasis contribute to the overall low survival rates associated with these cancers. Therefore, there is an urgent need to identify novel molecular targets for effective GI cancer treatment. Recent research has shed light on the potential of long non-coding RNAs (lncRNAs) as promising targets in cancer therapy, given their strong association with carcinogenesis and profound impact on tumor development. Among these lncRNAs, lncRNA-MUF, also known as LINC00941, has emerged as a key player in oncogenic regulation, specifically implicated in the progression of various GI cancers, including esophageal, gastric, colorectal, hepatic, and pancreatic cancer. This review aims to provide an updated and focused analysis of the regulatory roles of LINC00941 in the initiation and progression of GI cancer. Our objective is to unravel the underlying molecular mechanisms through which LINC00941 influences GI cancer phenotypes both in vivo and in vitro, with a special emphasis on the key molecules and signaling pathways involved. Additionally, LINC00941 has demonstrated clinical significance in terms of clinical pathology, prognosis, and diagnosis in GI tumors, further reinforcing its potential as a novel therapeutic target.

Introduction

Gastrointestinal (GI) cancers encompass a diverse range of malignancies affecting the digestive system, including the esophagus, stomach, liver, pancreas, and colorectum [1]. These cancers present substantial challenges, with a significant global burden of morbidity and mortality [2, 3]. In 2020 [4], colorectal cancer ranked third worldwide, comprising 10% of total tumor cases (10.1 million new cases), followed by stomach cancer (5.6%), liver cancer (4.7%), and oesophageal cancer (3.1%). Similarly, in terms of mortality, colorectal cancer ranked second globally, accounting for 9.4% of total deaths (5.5 million deaths), followed by liver cancer (8.3%), stomach cancer (7.7%), oesophageal cancer (5.5%), and pancreatic cancer (4.7%). Despite the advancement of treatment modalities, such as radiation therapy, and immunotherapy, have made [5-9], the prognosis for patients with GI cancers remains unsatisfactory, characterized by a high risk of disease recurrence and metastasis. Consequently, there is an urgent need to gain a comprehensive understanding of the intricate molecular mechanisms governing the development and progression of GI cancers to facilitate the development of efficacious therapeutic strategies.

In recent years, non-coding RNAs (ncRNAs), particularly long non-coding RNAs (lncRNAs), have emerged as important players in cancer biology [10-14]. LncRNAs have been found to be involved in a variety of biological processes, can act as oncogenes or tumor suppressors, and are associated with various aspects of cancer, including tumorigenesis, metastasis, and treatment resistance [15-19]. The aberrant expression patterns of lncRNAs in GI cancers have been linked to clinical outcomes, making them promising tumor markers and potential therapeutic targets [11, 20-26].

In the field of GI cancer research, considerable attention has been focused on the lncRNA-MUF, or MSC-upregulated factor. This particular lncRNA is also identified as Long Intergenic Non-Protein Coding RNA 941 (LINC00941). The LINC00941 gene is located at the 12p11.21 position within the human genome and is distinct in having just a single transcript. This singular transcript feature of the gene highlights its unique molecular characteristics in GI cancer studies. Recently, a large number of studies have shown that it is involved in the progression of various tumors [27-34], particularly in GI malignancies [35-47]. Dysregulated expression of LINC00941 has been observed in GI tumors [35, 43, 44, 46]. Functionally, LINC00941 has been shown to modulate multiple signaling pathways in GI cancers, exerting influence on critical tumor-related biological functions both in vivo and in vitro [35, 37, 40-42, 47], such as proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), tumor growth, and metastasis. Additionally, its expression has been correlated with clinical features and survival outcomes [35, 42, 45, 47], highlighting its potential as a biomarker for GI cancers.

 Figure 1 

LINC00941 contributes to gastrointestinal cancer development by exerting regulatory control over various biological processes through related genes and signaling pathways.

Here, we review the molecular mechanisms, cellular processes, and clinical implications associated with LINC00941 in GI cancers. We hope this will identify knowledge gaps and outline future research directions in this field. By providing a detailed assessment, this review aims to highlight the potential of LINC00941 as a promising candidate for a novel therapeutic target in GI cancers, offering new avenues to improve patient outcomes.

LINC00941 in gastrointestinal cancers

LINC00941 has been studied in various GI cancer types, including squamous cell carcinoma (ESCC) [35, 39], gastric cancer (GC) [45, 46], colorectal cancer (CRC) [41, 44], hepatocellular carcinoma (HCC) [47], and pancreatic cancer (PC) [36, 37, 40, 42, 43, 48, 49]. Research have shown that LINC00941 plays a regulatory role in GI development by influencing key molecules and genes involved in a series of biological processes, such as proliferation, invasion, migration, and EMT (Figure 1). In GI cancers, dysregulated expression of LINC00941 has been observed in cancer cells and tissues, and LINC00941 has been found to function as an oncogene and promote tumorigenesis and progression in GI cancers. Functionally, LINC00941 exerts regulatory functions in specific gene expression by interacting with related proteins at the transcriptional and/or post-transcriptional levels. LINC00941 also acts as a competing endogenous RNA (ceRNA) for binding to microRNA (miRNA), thereby upregulating gene expression. Furthermore, LINC00941 is implicated in the activation of multiple signaling pathways, such as TGF-β/SMAD signaling pathway, Wnt/β-catenin signaling, and Hippo signaling pathway, or regulated by signaling pathways, like MAPK/ERK pathway, as shown in Figure 2. The functional implications of LINC00941 have been explored through in vitro and/or in vivo experiments, shedding light on its critical involvement in GI cancer progression. In the subsequent sections, we discuss the specific outcomes and implications of these experiments in detail.

Studies utilizing cancer cell lines

In vitro studies investigating the role of LINC00941 in various GI cancer cell types have provided valuable insights into its functional effects. A range of cell-based functional assays, including proliferation, migration, invasion, tumor sphere formation, and glycolysis, were conducted to elucidate the impact of LINC00941. Table 1 presents the expression patterns of LINC00941 in GI cancer cell lines, along with their respective subcellular localizations and the corresponding functional assays employed. Figure 3 illustrates the functional roles of LINC00941 when either silenced or/and overexpressed in GI cell lines.

In ESCC cell lines, studies by Zhang et al. [39] and Lu et al. [35] reported that LINC00941 is significantly highly expressed in cancer cells compared to human esophageal epithelial cells. And LINC00941 was found to promote ESCC cell proliferation, invasion, migration, and stemness while inhibiting EMT. Mechanistically (Figure 4), the oncogenic role of LINC00941 involves interactions with the miR-877-3p/PMEPA1 axis [39] or a positive feedback loop involving LINC00941-ILF2/YBX1-SOX2 [35].

In GC cell lines, LINC00941 has the potential to modulate the metastatic properties of GC cells, particularly migration and invasion, by influencing the EMT process [45]. LINC00941 is up-regulated in CRC cells and contributes to cell proliferation, migration, and invasion by sponging miR-205-5p and upregulating MYC expression [44]. Notably, Wu et al [41] found that LINC00941 activates EMT in CRC by binding to the SMAD4 protein, preventing degradation, and activating the TGF-β/SMAD signaling pathway. The regulatory mechanism of LINC00941 in CRC is displayed in Figure 5.

 Figure 2 

Signaling pathways involved or regulated by LINC00941.

 Figure 3 

Functional impact of LINC00941 overexpression or silencing in vitro.

For HCC [47], LINC00941 is highly expressed in tumor spheres and highly invasive HCC cells. Overexpression of LINC00941 accelerates the activation of EMT and enhances the malignant capacity of HCC cells, while its suppression produces opposite effects. Mechanistically, LINC00941 promotes EMT by bounding ANXA2 and activating Wnt/β-catenin signaling or by acting as a competing endogenous RNA for miR-34a, leading to Snail1 upregulation.

Regarding to PC, LINC00941 is highly expressed in cancer cell lines and mainly located in the cytoplasm [37, 40, 42]. Overexpression of LINC00941 promotes cell proliferation, viability, invasion, migration, EMT, and stemness, while downregulation leads to the opposite effects. Specifically, LINC00941 could stimulate metastasis and EMT by competitively binding miR873-3p to upregulate ATXN2 [43] or act as a molecular sponge for miR-335-5p, thereby promoting ROCK1 upregulation, and activating LIMK1/Cofilin-1 pathway [42]. Wang et al [37] observed that LINC00941 could increase PC cell proliferation and enhance metastatic properties by upregulated ANXA2 and activating FAK/AKT signaling. And according to the study by Lu et al [36], LINC00941 was upregulated by METTL14 in an m6A-dependent way, contributing to the migration and invasion of PC cells. LINC00941 was also identified as the most upregulated lncRNA among MAPK-associated in PC [48], showing a positive relationship with cell proliferation in MIA PaCa-2 and AsPC-1 [48]. Furthermore, Xu et al [40] reported that LINC00941 promotes PDAC cancer cell growth by enhancing aerobic glycolysis, and mechanistically, LINC00941 interacts with MST1, leading to Hippo pathway activation, and enhancing glycolysis in PDAC [40]. A detailed regulatory mechanism of LINC00941 in pancreatic cancer is presented in Figure 6.

Studies using murine animal models

A number of research teams have extensively investigated the functional implications of manipulating LINC00941 expression in tumor development using xenograft models, including subcutaneous tumor models, tumor metastasis models, and orthotopic transplantation models, as detailed in Table 2 and Figure 7. Consistent with in vitro studies, LINC00941 has been reported to have oncogenic roles in gastrointestinal cancers.

In the case of ESCC [35, 39], in vivo knockdown of LINC00941 significantly attenuated tumor progression, while its overexpression promoted tumor growth and metastasis. In GC [45], modulation of LINC00941 affected tumor growth, resulting in smaller tumors and reduced weight upon knockdown. Similarly, in CRC [41, 44], LINC00941 knockdown impaired tumor growth, metastasis, and the formation of lung nodules, while its overexpression increased the number of lung metastatic nodules. Depletion of LINC00941 in HCC suppressed xenograft formation and metastasis, leading to smaller tumors and a decreased number of liver nodules [47]. In PC [36, 37, 40, 42, 43, 48, 49], LINC00941 played a significant role in promoting tumor growth, metastasis, and the expression of proliferation and glycolysis-related markers. Conversely, depletion of LINC00941 resulted in reduced tumor size, growth rate, metastases, and improved prognosis. These collective findings highlight the pivotal role of LINC00941 in tumor development and underscore its potential as a promising therapeutic target in various gastrointestinal cancers.

Studies with clinical patient samples

The expression of LINC00941 showed significant up-regulation in various GI cancers. This up-regulation was confirmed through multiple methodologies, such as database analysis, reverse transcription quantitative polymerase chain reaction (RT-qPCR), and in situ hybridization (ISH). A summary of LINC00941 expression and its associations with pathological features, prognosis, and diagnostic value in clinical settings of GI tumors is presented in Table 3.

 Figure 4 

Regulatory mechanisms of LINC00941 in esophageal squamous cell carcinoma.

 Figure 5 

Regulatory mechanisms of LINC00941 in colorectal cancer.

In ESCC [35, 39], elevated expression of LINC00941 in tumor tissues suggests its potential role in ESCC progression. Furthermore, high expression levels of LINC00941 were significantly associated with poor five-year survival rates in ESCC patients [35]. Similarly, in GC [45, 46], LINC00941 was up-regulated in cancer tissues and exhibited a significant correlation with clinicopathological features, including invasion depth, lymphatic metastasis, and TNM stage. These findings highlight the diagnostic and prognostic potential of LINC00941 in GC, as it can discriminate between different pathological tissue samples and predict patient survival time. In CRC, LINC00941 displayed amplified expression in cancer tissues and showed significant associations with clinical characteristics such as tumor invasive depth, metastasis, and stage (41). Notably, patients with higher expression levels of LINC00941 experienced significantly shorter overall survival times [41], indicating its potential as an independent risk factor for poor prognosis in CRC. Consistent with the other cancers, HCC specimens exhibited consistently high expression levels of LINC00941 compared to adjacent non-tumor tissues. Kaplan-Meier survival analysis further demonstrated a correlation between elevated LINC00941 expression and poor survival outcomes in HCC patients [47, 50]. Moreover, elevated levels of LINC00941 were detected in the serum of HCC patients (35), suggesting its potential as a non-invasive diagnostic biomarker for HCC. In PC, LINC00941 expression was found to be higher in pancreatic cancer tissues, and its localization was primarily observed in the cytosol of tumor cells. LINC00941 expression positively correlated with advanced pathological features [36, 40, 42], and higher expression levels of LINC00941 were associated with unfavorable prognoses in PC patients [36, 37, 40, 42, 43, 48, 49], further highlighting its significance as a prognostic biomarker for PC. Overall, the consistent upregulation of LINC00941 in various gastrointestinal cancers and its association with clinical features and patient outcomes shows its potential as a valuable biomarker for diagnosis, prognosis and risk assessment of these diseases.

Future perspectives and conclusion

LINC00941 has recently attracted considerable attention in gastrointestinal oncology research. Based on available literature, LINC00941 has been studied in five common types of human gastrointestinal cancers, namely, esophageal, gastric, colorecta, hepatocellular, and pancreatic cancers. In vitro experiments have revealed its oncogenic role in many cellular processes (Figure 3), including promoting proliferation, migration, invasion, EMT, and enhancing stemness, and facilitating glycolysis. Moreover, murine animal models also have been employed. In xenograft models, LINC00941 silencing has consistently shown inhibitory effects on tumor progression, reducing tumor growth and metastasis. Conversely, overexpression of LINC00941 has been associated with enhanced tumor growth and metastatic potential (Figure 7). At the molecular level, LINC00941 mainly functions as a ceRNA, upregulating downstream gene expressions by competing for specific microRNAs (miR-877-3p, miR-205-5p, miR-34a, miR-873-3p, and miR-335-5p) [39, 42-44, 47]. Additionally, it also regulates gene expression at the transcriptional and/or post-transcriptional levels through interactions with related proteins, and further contributing to the initiation and progression of GI cancers via activation of critical signaling pathways (Hippo signaling pathway, TGF-β/SMAD signaling pathway, Wnt/b-catenin signaling, EMT pathway, FAK/AKT signaling, and LIMK1/Cofilin-1 pathway) [37, 40-42, 47]. Collectively, these findings provide valuable insights into the functional role of LINC00941 in tumor development, highlighting its potential as a target for therapeutic interventions.

 Figure 6 

Regulatory mechanisms of LINC00941 in pancreatic cancer.

 Figure 7 

Functional impact of LINC00941 overexpression or silencing in vivo.

In addition, numerous studies have consistently demonstrated that the expression of LINC00941 is upregulated in comparison to normal tissues and cell lines, implying its potential involvement in gastrointestinal tumorigenesis. Furthermore, LINC00941 expression is closely linked to advanced tumor characteristics in various types of gastrointestinal cancer, suggesting its potential role in promoting tumor progression and metastasis. The heightened expression of LINC00941 has been associated with an unfavorable prognosis in ESCC, CRC, HCC and PC. This underscores LINC00941's potential as an independent risk factor for poor prognosis in these cancer types. In terms of diagnosis, LINC00941 has shown potential as a diagnostic biomarker for GC and HCC. Overall, the upregulation of LINC00941 in gastrointestinal cancers and its correlation with clinicopathological features, as well as its value as both a prognostic and diagnostic biomarker, highlight its significance in comprehending the pathogenesis and clinical management of these cancers. Nevertheless, further research is required to validate the diagnostic and prognostic value of LINC00941 in gastrointestinal tumors within a larger and more diverse patient population.

Despite the progress made, the functional role and clinical value of LINC00941 in gastrointestinal tumors remain incompletely understood, posing several challenges and unanswered questions that warrant exploration. Firstly, the potential involvement of LINC00941 in other gastrointestinal tumors, such as gallbladder cancer, gastrointestinal stromal tumors, small intestine tumors, and bile duct cancer, remains unexplored so far and requires investigation. Additionally, the relationship between LINC00941 and chemotherapy and radiotherapy resistance in gastrointestinal tumors is currently unclear. Although existing studies have shown that a variety of long non-coding RNAs are associated with tumor therapy resistance [51-55], whether LINC00941 is involved in the resistance in the treatment of gastrointestinal tumors is still unknown, but it is worth revealing. Moreover, there is a need for further investigation into the expression of LINC00941 in fluid tissues, such as serum, and its potential as a prognostic and diagnostic marker in gastrointestinal tumors. Non-coding RNAs in fluid tissues have shown promise as tumor markers and diagnostic indicators [56-58]. It is of great significance to explore the expression level of LINC00941 in liquid tissues and its correlation with the prognosis and diagnosis of patients with gastrointestinal tumors.

 Figure 8 

LINC00941 is involved in the progression of gastrointestinal cancer and its application prospect as a biomarker and therapeutic target of gastrointestinal cancer.

In summary, LINC00941 may hold promise as a tumor marker and therapeutic target in GI cancers (Figure 8). It has emerged as a valuable tool for clinical prognosis and diagnosis, offering potential avenues for targeted interventions in GI tumors. The expression of LINC00941 can be regulated by related proteins interacting with its DNA promoter, and LINC00941 can participate in the lncRNA-miRNA ceRNA network and regulate lncRNA-protein or lncRNA-mRNA interactions. These mechanisms collectively contribute to the significant involvement of LINC00941 in the development and progression of GI tumors, influencing multiple oncogenic signaling pathways and malignancy-related behaviors. These findings underscore the potential of LINC00941 as a predictive biomarker and an attractive target for GI cancers. Further experimental investigations are necessary to fully elucidate the underlying mechanisms of LINC00941 and establish robust theoretical support. Future clinical studies focusing on LINC00941 are imperative to uncover innovative ideas and approaches for GI cancer diagnosis, risk stratification, and treatment.

Abbreviations

GI: Gastrointestinal; ncRNAs: non-coding RNAs; lncRNAs: long non-coding RNAs; lncRNA-MUF: MSC-upregulated factor; LINC00941: Long Intergenic Non-Protein Coding RNA 941; EMT: epithelial-mesenchymal transition; ESCC: esophageal squamous cell carcinoma; GC: gastric cancer; CRC: colorectal cancer; HCC: hepatocellular carcinoma; PC: pancreatic cancer; ceRNA: competing endogenous RNA; miRNA: microRNA; RT-qPCR: reverse transcription quantitative polymerase chain reaction; ISH: in situ hybridization.

Author contributions

Every author has significantly contributed to the conception, design, execution, and analysis of this study, participated in drafting or revising the manuscript, approved the final version to be published, agreed on the journal for submission, and collectively assumes responsibility for the work's integrity and accuracy.

Competing Interests

The authors have declared that no competing interest exists.

References

1. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P. et al. The 2019 WHO classification of tumours of the digestive system. Histopathology. 2020;76:182-8

2. Arnold M, Abnet CC, Neale RE, Vignat J, Giovannucci EL, McGlynn KA. et al. Global Burden of 5 Major Types of Gastrointestinal Cancer. Gastroenterology. 2020;159:335-49.e15

3. Jardim SR, de Souza LMP, de Souza HSP. The Rise of Gastrointestinal Cancers as a Global Phenomenon: Unhealthy Behavior or Progress? International journal of environmental research and public health. 2023 20

4. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A. et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: a cancer journal for clinicians. 2021;71:209-49

5. Joshi SS, Badgwell BD. Current treatment and recent progress in gastric cancer. CA: a cancer journal for clinicians. 2021;71:264-79

6. Grierson P, Lim KH, Amin M. Immunotherapy in gastrointestinal cancers. Journal of gastrointestinal oncology. 2017;8:474-84

7. Rao D, Parakrama R, Augustine T, Liu Q, Goel S, Maitra R. Immunotherapeutic advances in gastrointestinal malignancies. NPJ precision oncology. 2019;3:4

8. Buckley AM, Lynam-Lennon N, O'Neill H, O'Sullivan J. Targeting hallmarks of cancer to enhance radiosensitivity in gastrointestinal cancers. Nature reviews Gastroenterology & hepatology. 2020;17:298-313

9. Beltran C, Schultz HL, Anand A, Merrell K. Radiation biology considerations of proton therapy for gastrointestinal cancers. Journal of gastrointestinal oncology. 2020;11:225-30

10. Grafanaki K, Grammatikakis I, Ghosh A, Gopalan V, Olgun G, Liu H. et al. Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response. Pharmacology & therapeutics. 2023;248:108466

11. Ashrafizadeh M, Mohan CD, Rangappa S, Zarrabi A, Hushmandi K, Kumar AP. et al. Noncoding RNAs as regulators of STAT3 pathway in gastrointestinal cancers: Roles in cancer progression and therapeutic response. Medicinal research reviews. 2023

12. Al-Noshokaty TM, Mansour A, Abdelhamid R, Abdellatif N, Alaaeldien A, Reda T. et al. Role of long non-coding RNAs in pancreatic cancer pathogenesis and treatment resistance- A review. Pathology, research and practice. 2023;245:154438

13. Li X, Huang H, Liu M, Luo H. Tumor Suppressor LncRNA on Chromosome 8p12 (TSLNC8): A Concise Review in Human Malignancies. J Cancer. 2023;14:2867-77

14. Zhu N, Chen X, Zhao J, Fang L, Yao Y, Zhou F. et al. Hypoxia-induced LINC00674 facilitates hepatocellular carcinoma progression by activating the NOX1/mTOR signaling pathway. J Cancer. 2022;13:3177-88

15. Ghafouri-Fard S, Harsij A, Hussen BM, Taheri M, Sharifi G. A review on the role of CASC11 in cancers. Frontiers in cell and developmental biology. 2023;11:1131199

16. Chao C, Tang R, Zhao J, Di D, Qian Y, Wang B. Oncogenic roles and related mechanisms of the long non-coding RNA MINCR in human cancers. Frontiers in cell and developmental biology. 2023;11:1087337

17. Zhou FJ, Meng S, Wu XF, Hou PF, Li ML, Chu SF. et al. LncRNA LINC00460 facilitates the proliferation and metastasis of renal cell carcinoma via PI3K/AKT signaling pathway. Journal of Cancer. 2022;13:2844-54

18. Zhang Y, Zhang Y, Zeng Q, Li C, Zhou H, Liu J. et al. IL-1β-Triggered Long Non-coding RNA CHRF Induces Non-Small Cell Lung Cancer by Modulating the microRNA-489/Myd88 Axis. Journal of Cancer. 2022;13:2620-30

19. Zhang F, Chen Q, Chen P, Liu C, Wang H, Zhao L. The lncRNA CRNDE is regulated by E2F6 and sensitizes gastric cancer cells to chemotherapy by inhibiting autophagy. Journal of Cancer. 2022;13:3061-72

20. Hamid UZ, Sim MS, Guad RM, Subramaniyan V, Sekar M, Fuloria NK. et al. Molecular Regulatory Roles of Long Non-coding RNA HOTTIP: An Overview in Gastrointestinal Cancers. Current molecular medicine. 2022;22:478-90

21. Ramli S, Sim MS, Guad RM, Gopinath SCB, Subramaniyan V, Fuloria S. et al. Long Noncoding RNA UCA1 in Gastrointestinal Cancers: Molecular Regulatory Roles and Patterns, Mechanisms, and Interactions. Journal of oncology. 2021;2021:5519720

22. Khajehdehi M, Khalaj-Kondori M, Ghasemi T, Jahanghiri B, Damaghi M. Long Noncoding RNAs in Gastrointestinal Cancer: Tumor Suppression Versus Tumor Promotion. Digestive diseases and sciences. 2021;66:381-97

23. Dragomir MP, Kopetz S, Ajani JA, Calin GA. Non-coding RNAs in GI cancers: from cancer hallmarks to clinical utility. Gut. 2020;69:748-63

24. Yuan HH, Zhang XC, Wei XL, Zhang WJ, Du XX, Huang P. et al. LncRNA UCA1 mediates Cetuximab resistance in Colorectal Cancer via the MiR-495 and HGF/c-MET Pathways. J Cancer. 2022;13:253-67

25. Xiao L, Yuan W, Huang C, Luo Q, Xiao R, Chen ZH. LncRNA PCAT19 induced by SP1 and acted as oncogene in gastric cancer competitively binding to miR429 and upregulating DHX9. J Cancer. 2022;13:102-11

26. Wang S, Wang Y, Zhang Z, Zhu C, Wang C, Yu F. et al. Long Non-Coding RNA NRON promotes Tumor Proliferation by regulating ALKBH5 and Nanog in Gastric Cancer. Journal of Cancer. 2021;12:6861-72

27. Wang Y, Zhao D, Wang H, Wang S, Zhang H, Liu H. et al. Long non-coding RNA-LINC00941 promotes the proliferation and invasiveness of glioma cells. Neuroscience letters. 2023;795:136964

28. Wang Y, Wang S, Wang H, Zhao D, Zhang H, Liu H. et al. Knockdown of long non-coding RNA LINC00941 suppressed cell proliferation, colony-formation, and migration of human glioblastoma cell lines. Folia Neuropathologica. 2023;61:209-16

29. Qiu L, Zhou R, Zhou L, Yang S, Wu J. CAPRIN2 upregulation by LINC00941 promotes nasopharyngeal carcinoma ferroptosis resistance and metastatic colonization through HMGCR. Frontiers in oncology. 2022;12:931749

30. Liu J, Li Z, Zhang T, Wang C, Chen W, Zhang D. et al. Long Noncoding RNA LINC00941 Promotes Cell Proliferation and Invasion by Interacting with hnRNPK in Oral Squamous Cell Carcinoma. Nutrition and cancer. 2022;74:2983-95

31. Li Z, Jin Q, Sun Y. LINC00941 promoted in vitro progression and glycolysis of laryngocarcinoma by upregulating PKM via activating the PI3K/AKT/mTOR signaling pathway. Journal of clinical laboratory analysis. 2022;36:e24406

32. Ren MH, Chen S, Wang LG, Rui WX, Li P. LINC00941 Promotes Progression of Non-Small Cell Lung Cancer by Sponging miR-877-3p to Regulate VEGFA Expression. Frontiers in oncology. 2021;11:650037

33. Gugnoni M, Manicardi V, Torricelli F, Sauta E, Bellazzi R, Manzotti G. et al. Linc00941 Is a Novel Transforming Growth Factor β Target That Primes Papillary Thyroid Cancer Metastatic Behavior by Regulating the Expression of Cadherin 6. Thyroid: official journal of the American Thyroid Association. 2021;31:247-63

34. Ai Y, Wu S, Zou C, Wei H. LINC00941 promotes oral squamous cell carcinoma progression via activating CAPRIN2 and canonical WNT/β-catenin signaling pathway. Journal of cellular and molecular medicine. 2020;24:10512-24

35. Lu JT, Yan ZY, Xu TX, Zhao F, Liu L, Li F. et al. Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma. Cell death & disease. 2023;14:72

36. Lu J, Yu L, Xie N, Wu Y, Li B. METTL14 Facilitates the Metastasis of Pancreatic Carcinoma by Stabilizing LINC00941 in an m6A-IGF2BP2-Dependent Manner. J Cancer. 2023;14:1117-31

37. Wang J, He Z, Liu X, Xu J, Jiang X, Quan G. et al. LINC00941 promotes pancreatic cancer malignancy by interacting with ANXA2 and suppressing NEDD4L-mediated degradation of ANXA2. Cell death & disease. 2022;13:718

38. Chen J, Tang D, Li H, Zhang P. Expression changes of serum LINC00941 and LINC00514 in HBV infection-related liver diseases and their potential application values. Journal of clinical laboratory analysis. 2022;36:e24143

39. Zhang Y, Zhu H, Sun N, Zhang X, Liang G, Zhu J. et al. Linc00941 regulates esophageal squamous cell carcinoma via functioning as a competing endogenous RNA for miR-877-3p to modulate PMEPA1 expression. Aging. 2021;13:17830-46

40. Xu M, Cui R, Ye L, Wang Y, Wang X, Zhang Q. et al. LINC00941 promotes glycolysis in pancreatic cancer by modulating the Hippo pathway. Molecular therapy Nucleic acids. 2021;26:280-94

41. Wu N, Jiang M, Liu H, Chu Y, Wang D, Cao J. et al. LINC00941 promotes CRC metastasis through preventing SMAD4 protein degradation and activating the TGF-β/SMAD2/3 signaling pathway. Cell death and differentiation. 2021;28:219-32

42. Wang J, He Z, Xu J, Chen P, Jiang J. Long noncoding RNA LINC00941 promotes pancreatic cancer progression by competitively binding miR-335-5p to regulate ROCK1-mediated LIMK1/Cofilin-1 signaling. Cell death & disease. 2021;12:36

43. Fang L, Wang SH, Cui YG, Huang L. LINC00941 promotes proliferation and metastasis of pancreatic adenocarcinoma by competitively binding miR-873-3p and thus upregulates ATXN2. European review for medical and pharmacological sciences. 2021;25:1861-8

44. Chang L, Zhou D, Luo S. Novel lncRNA LINC00941 Promotes Proliferation and Invasion of Colon Cancer Through Activation of MYC. OncoTargets and therapy. 2021;14:1173-86

45. Liu H, Wu N, Zhang Z, Zhong X, Zhang H, Guo H. et al. Long Non-coding RNA LINC00941 as a Potential Biomarker Promotes the Proliferation and Metastasis of Gastric Cancer. Frontiers in genetics. 2019;10:5

46. Luo C, Tao Y, Zhang Y, Zhu Y, Minyao DN, Haleem M. et al. Regulatory network analysis of high expressed long non-coding RNA LINC00941 in gastric cancer. Gene. 2018;662:103-9

47. Yan X, Zhang D, Wu W, Wu S, Qian J, Hao Y. et al. Mesenchymal Stem Cells Promote Hepatocarcinogenesis via lncRNA-MUF Interaction with ANXA2 and miR-34a. Cancer research. 2017;77:6704-16

48. Ishikawa T, Fukushige S, Saiki Y, Hirose K, Hiyoshi T, Ogawa T. et al. Long Non-Coding RNAs Associated with Mitogen-Activated Protein Kinase in Human Pancreatic Cancer. Cancers. 2023 15

49. Ke M. Identification and Validation of Apparent Imbalanced Epi-lncRNAs Prognostic Model Based on Multi-Omics Data in Pancreatic Cancer. Frontiers in molecular biosciences. 2022;9:860323

50. Fang Y, Yang Y, Zhang X, Li N, Yuan B, Jin L. et al. A Co-Expression Network Reveals the Potential Regulatory Mechanism of lncRNAs in Relapsed Hepatocellular Carcinoma. Frontiers in oncology. 2021;11:745166

51. Yin J, Ding F, Cheng Z, Ge X, Li Y, Zeng A. et al. METTL3-mediated m6A modification of LINC00839 maintains glioma stem cells and radiation resistance by activating Wnt/β-catenin signaling. Cell death & disease. 2023;14:417

52. Shao Y, Li H, Wu Y, Wang X, Meng J, Hu Z. et al. The feedback loop of AURKA/DDX5/TMEM147-AS1/let-7 drives lipophagy to induce cisplatin resistance in epithelial ovarian cancer. Cancer letters. 2023;565:216241

53. Qu X, Liu B, Wang L, Liu L, Zhao W, Liu C. et al. Loss of cancer-associated fibroblast-derived exosomal DACT3-AS1 promotes malignant transformation and ferroptosis-mediated oxaliplatin resistance in gastric cancer. Drug resistance updates: reviews and commentaries in antimicrobial and anticancer chemotherapy. 2023;68:100936

54. Chen X, Ding JC, Hu GS, Shu XY, Liu Y, Du J. et al. Estrogen-Induced LncRNA, LINC02568, Promotes Estrogen Receptor-Positive Breast Cancer Development and Drug Resistance Through Both In Trans and In Cis Mechanisms. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023: e2206663.

55. Chen H, Wang L, Liu J, Wan Z, Zhou L, Liao H. et al. LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell lung cancer by inhibiting ferroptosis via activating the FOSL2/NAMPT axis. Cancer biology & therapy. 2023;24:2223377

56. Kim T, Reitmair A. Non-Coding RNAs: Functional Aspects and Diagnostic Utility in Oncology. International journal of molecular sciences. 2013;14:4934-68

57. He Y, Xiao B, Lei T, Xuan J, Zhu Y, Kuang Z. et al. LncRNA T376626 is a promising serum biomarker and promotes proliferation, migration, and invasion via binding to LAMC2 in triple-negative breast cancer. Gene. 2023;860:147227

58. Koopaie M, Kolahdooz S, Fatahzadeh M, Aleedawi ZA. Salivary noncoding RNA in the diagnosis of pancreatic cancer: Systematic review and meta-analysis. European journal of clinical investigation. 2022;52:e13848

Author contact

Corresponding authors: Hongliang Luo (ndefy13028edu.cn) and Huazhao Yuan (yuanhuazhao1036com).

Received 2023-11-17
Accepted 2023-12-30
Published 2024-1-21

Citation styles

©2024 Ivyspring International Publisher. Terms of use