1. Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. 2. Department of Biochemistry and Molecular Biology, Metabolic Disease Research Center, School of Basic Medicine, Anhui Medical University, Hefei 230032, China. 3. Anhui Provincial Institute of Translational Medicine, Hefei 230032, China. 4. Department of Dermatology, First Affiliated Hospital of Anhui Medical University, Hefei 230032, China. *Contributed equally to this work.
✉ Corresponding authors: Address: Department of General Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, China, E-mail: chenwei366edu.cn (W. Chen); Address: Department of Biochemistry & Molecular Biology, School of Basic Medicine, Anhui Medical University, Hefei 230032, China, E-mail: slzhang1977com and huabingzhangedu.cn (H. Zhang).More
Citation:
Sun R, Tu X, Chan S, Wang X, Ji Y, Wang Z, Yu Z, Zuo X, Zhang Q, Chen J, Han Q, Wang M, Zhao H, Zhang H, Chen W. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. J Cancer 2024; 15(8):2123-2136. doi:10.7150/jca.92633. https://www.jcancer.org/v15p2123.htm
Colorectal cancer (CRC) seriously endangers human health owing to its high morbidity and mortality. Previous studies have suggested that high expression of CBX2 may be associated with poor prognosis in CRC patients. However, its functional role in CRC remains to be elucidated. Herein, we found that CBX2 overexpression in colorectal cancer tissue compared with adjacent tissues. Additionally, forest maps and the nomogram model indicated that elevated CBX2 expression was an independent prognostic factor in CRC. Moreover, we confirmed that the deletion of CBX2 markedly suppressed the proliferation and migration of CRC cells in vitro and in vivo. Furthermore, downregulation of CBX2 promotes CRC cell apoptosis and hinders the cell cycle. Mechanistically, our data demonstrated that deletion of CBX2 inhibited the MAPK signaling pathway by regulating the protein levels of Mettl3. In conclusion, our study demonstrated that CBX2 is a vital tumor suppressor in CRC and could be a promising anti-cancer therapeutic target.
Keywords: CBX2, METTL3, MAPK signal pathway, proliferation, metastasis, liver metastasis
Citation styles
APA
Sun, R., Tu, X., Chan, S., Wang, X., Ji, Y., Wang, Z., Yu, Z., Zuo, X., Zhang, Q., Chen, J., Han, Q., Wang, M., Zhao, H., Zhang, H., Chen, W. (2024). CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. Journal of Cancer, 15(8), 2123-2136. https://doi.org/10.7150/jca.92633.
ACS
Sun, R.; Tu, X.; Chan, S.; Wang, X.; Ji, Y.; Wang, Z.; Yu, Z.; Zuo, X.; Zhang, Q.; Chen, J.; Han, Q.; Wang, M.; Zhao, H.; Zhang, H.; Chen, W. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. J. Cancer 2024, 15 (8), 2123-2136. DOI: 10.7150/jca.92633.
NLM
Sun R, Tu X, Chan S, Wang X, Ji Y, Wang Z, Yu Z, Zuo X, Zhang Q, Chen J, Han Q, Wang M, Zhao H, Zhang H, Chen W. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. J Cancer 2024; 15(8):2123-2136. doi:10.7150/jca.92633. https://www.jcancer.org/v15p2123.htm
CSE
Sun R, Tu X, Chan S, Wang X, Ji Y, Wang Z, Yu Z, Zuo X, Zhang Q, Chen J, Han Q, Wang M, Zhao H, Zhang H, Chen W. 2024. CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway. J Cancer. 15(8):2123-2136.
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