Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells

Han, Shuangze; Chen, Sijin; Wang, Jidong; Huang, Sheng; Xiao, Yeqing; Deng, Gaoyan

doi:10.7150/jca.92780

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J Cancer 2024; 15(8):2380-2390. doi:10.7150/jca.92780 This issue Cite

Research Paper

Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells

Shuangze Han^2#, Sijin Chen^3#, Jidong Wang^4#, Sheng Huang⁵, Yeqing Xiao⁶, Gaoyan Deng^1✉

1. Department of Thoracic Surgery, Hunan Chest Hospital, Changsha 410013, Hunan, China.
2. Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
3. Department of Urology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha 410005, Hunan, China.
4. Department of Oral and Maxillofacial Surgery, Changde Hospital, Xiangya School of Medicine, Central South University (The first people's hospital of Changde city), Changde 415000, Hunan, China.
5. Department of General, Hunan Chest Hospital, Changsha 410013, Hunan, China.
6. Department of Ultrasonography, Hunan Chest Hospital, Changsha 410013, Hunan, China.
# These authors contributed equally to this work.

Citation:

Han S, Chen S, Wang J, Huang S, Xiao Y, Deng G. Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells. J Cancer 2024; 15(8):2380-2390. doi:10.7150/jca.92780. https://www.jcancer.org/v15p2380.htm

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Abstract

Highly activated aerobic glycolysis provides the metabolic requirements for tumor cell growth and proliferation. Erianin, a natural product isolated from Dendrobium chrysotoxum Lindl, has been reported to exert antitumor activity in multiple cancers. However, whether Erianin exerts inhibitory effects on aerobic glycolysis and the inherent mechanism remain poorly defined in non-small cell lung cancer (NSCLC). Here, we showed that Erianin inhibited the cell viability and proliferation, and induced apoptosis in NSCLC cells. Moreover, Erianin overtly suppressed aerobic glycolysis via decreasing HK2 expression. Mechanistically, Erianin dose-dependently curbed the Akt-GSK3β signaling pathway phosphorylation activation, which afterwards downregulated HK2 expression. Meanwhile, Erianin inhibited HCC827 tumor growth in vivo. Taken together, our results suggest that the natural product Erianin can suppress aerobic glycolysis and exert potent anticancer effects via the Akt-GSK3β signaling pathway in NSCLC cells.

Keywords: erianin, aerobic glycolysis, HK2, non-small cell lung cancer

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APA

Han, S., Chen, S., Wang, J., Huang, S., Xiao, Y., Deng, G. (2024). Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells. Journal of Cancer, 15(8), 2380-2390. https://doi.org/10.7150/jca.92780.

ACS

Han, S.; Chen, S.; Wang, J.; Huang, S.; Xiao, Y.; Deng, G. Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells. J. Cancer 2024, 15 (8), 2380-2390. DOI: 10.7150/jca.92780.

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CSE

Han S, Chen S, Wang J, Huang S, Xiao Y, Deng G. 2024. Erianin promotes apoptosis and inhibits Akt-mediated aerobic glycolysis of cancer cells. J Cancer. 15(8):2380-2390.

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