J Cancer 2014; 5(4):281-290. doi:10.7150/jca.8016 This issue


Current Approaches and Challenges in Early Detection of Breast Cancer Recurrence

Erika J. Schneble1✉, Lindsey J. Graham1, Matthew P. Shupe1, Frederick L. Flynt1, Kevin P. Banks1, Aaron D. Kirkpatrick1, Aviram Nissan2, Leonard Henry3, Alexander Stojadinovic4, Nathan M. Shumway1, Itzhak Avital4, George E. Peoples1, Robert F. Setlik1

1. San Antonio Military Medical Center (SAMMC), 3551 Roger Brooke Dr., Ft. Sam Houston, TX 78234, USA
2. Hadassah Medical Center, Kiryat Hadassah, POB 12000, Jerusalem, 91120, Israel
3. IU Health Goshen, 200 High Park Ave., Goshen, IN 46526, USA
4. Bon Secours Cancer Institute, 5855 Bremo Road, Richmond, VA 23226, USA

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Schneble EJ, Graham LJ, Shupe MP, Flynt FL, Banks KP, Kirkpatrick AD, Nissan A, Henry L, Stojadinovic A, Shumway NM, Avital I, Peoples GE, Setlik RF. Current Approaches and Challenges in Early Detection of Breast Cancer Recurrence. J Cancer 2014; 5(4):281-290. doi:10.7150/jca.8016. Available from https://www.jcancer.org/v05p0281.htm

File import instruction


Early detection of breast cancer recurrence is a key element of follow-up care and surveillance after completion of primary treatment. The goal is to improve survival by detecting and treating recurrent disease while potentially still curable assuming a more effective salvage surgery and treatment. In this review, we present the current guidelines for early detection of recurrent breast cancer in the adjuvant setting. Emphasis is placed on the multidisciplinary approach from surgery, medical oncology, and radiology with a discussion of the challenges faced within each setting.

Keywords: Breast cancer, Recurrence, Adjuvant, Surveillance, Follow-up