J Cancer 2015; 6(9):913-921. doi:10.7150/jca.12162 This issue Cite

Research Paper

Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects

Xiao-Yan Bai1, Xinjian Qu2, Xiao Jiang1, Zhaowei Xu1, Yangyang Yang1, Qiming Su2, Miao Wang1✉, Huijian Wu1, 2✉

1. School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China
2. School of Life Science and Medicine, Dalian University of Technology, Panjin, China

Citation:
Bai XY, Qu X, Jiang X, Xu Z, Yang Y, Su Q, Wang M, Wu H. Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects. J Cancer 2015; 6(9):913-921. doi:10.7150/jca.12162. https://www.jcancer.org/v06p0913.htm
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Abstract

We attempted to systematically determine the association between dietary intake of vitamin C and risk of prostate cancer. PubMed and Embase were searched to obtain eligible studies published before February 2015. Cohort or case-control studies that reported the relative risk (RR)/odds ratio (OR) estimates with 95% confidence intervals (CIs) for the association between vitamin C intake and prostate cancer risk were included. Eighteen studies regarding dietary vitamin C intake were finally obtained, with a total of 103,658 subjects. The pooled RR of prostate cancer for the highest versus the lowest categories of dietary vitamin C intake was 0.89 (95%CI: 0.83-0.94; p = 0.000) with evidence of a moderate heterogeneity (I2 = 39.4%, p = 0.045). Meta-regression analysis suggested that study design accounted for a major proportion of the heterogeneity. Stratifying the overall study according to study design yielded pooled RRs of 0.92 (95%CI: 0.86-0.99, p = 0.027) among cohort studies and 0.80 (95%CI: 0.71-0.89, p = 0.000) among case-control studies, with no heterogeneity in either subgroup. In the dose-response analysis, an inverse linear relationship between dietary vitamin C intake and prostate cancer risk was established, with a 150 mg/day dietary vitamin C intake conferred RRs of 0.91 (95%CI: 0.84-0.98, p = 0.018) in the overall studies, 0.95 (95%CI: 0.90-0.99, p = 0.039) in cohort studies, and 0.79 (95%CI: 0.69-0.91, p = 0.001) in case-control studies. In conclusion, intake of vitamin C from food was inversely associated with prostate cancer risk in this meta-analysis.

Keywords: vitamin C, dietary intake, prostate cancer, risk, meta-analysis


Citation styles

APA
Bai, X.Y., Qu, X., Jiang, X., Xu, Z., Yang, Y., Su, Q., Wang, M., Wu, H. (2015). Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects. Journal of Cancer, 6(9), 913-921. https://doi.org/10.7150/jca.12162.

ACS
Bai, X.Y.; Qu, X.; Jiang, X.; Xu, Z.; Yang, Y.; Su, Q.; Wang, M.; Wu, H. Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects. J. Cancer 2015, 6 (9), 913-921. DOI: 10.7150/jca.12162.

NLM
Bai XY, Qu X, Jiang X, Xu Z, Yang Y, Su Q, Wang M, Wu H. Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects. J Cancer 2015; 6(9):913-921. doi:10.7150/jca.12162. https://www.jcancer.org/v06p0913.htm

CSE
Bai XY, Qu X, Jiang X, Xu Z, Yang Y, Su Q, Wang M, Wu H. 2015. Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects. J Cancer. 6(9):913-921.

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