J Cancer 2016; 7(12):1680-1693. doi:10.7150/jca.15494 This issue

Research Paper

GSTT1 Null Genotype Significantly Increases the Susceptibility to Urinary System Cancer: Evidences from 63,876 Subjects

Ying Wang1#, Jing He2,3#, Tian-Jiao Ma4#, Wei Lei1, Feng Li5, Han Shen1, Zhen-Ya Shen1✉

1. Department of Cardiovascular Surgery of the First Affiliated Hospital& Institute for Cardiovascular Science, Soochow University, Suzhou, Jiangsu, China
2. Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Department of Experimental Research, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, Guangdong, China.
3. Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China
4. Department of Internal Medicine, Harbin Medical University, Harbin 150081, Heilongjiang, China
5. Department of Urinary Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
#These authors contributed equally to this work.

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Wang Y, He J, Ma TJ, Lei W, Li F, Shen H, Shen ZY. GSTT1 Null Genotype Significantly Increases the Susceptibility to Urinary System Cancer: Evidences from 63,876 Subjects. J Cancer 2016; 7(12):1680-1693. doi:10.7150/jca.15494. Available from https://www.jcancer.org/v07p1680.htm

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GSTT1 gene plays an important role in detoxification and clearance of reactive oxygen species(ROS). A null variant in this gene has been demonstrated to confer cancer susceptibility. Although many studies have demonstrated the association between GSTT1 null polymorphism and urinary system cancer susceptibility, several publications reported opposite conclusions. For better understanding the effects of this polymorphism on the risk of urinary system cancer, a updated meta-analysis was performed with a total of 26,666 cases and 37,210 controls extracted from 117 studies, by following the latest meta-analysis guidelines (PRISMA). The results suggested that the GSTT1 null genotype was significantly associated with an increased risk of urinary system cancer (OR=1.13, 95%CI=1.05-1.22). Furthermore, stratified analyses by the type of cancer, ethnicity, source of control and quality score presented a significantly increased risk associated with GSTT1 null genotype in bladder and prostate cancer subgroup, Caucasians and Indians subgroup, population-based(PB) subgroup, medium quality and low quality subgroup. Overall, our meta-analysis suggested that GSTT1 null genotype is a potential cancer susceptibility variant. Well-designed and large-cohort studies are needed to confirm the association between GSTT1 null genotype and urinary system cancer risk.

Keywords: GSTT1, meta-analysis, oxidative stress, polymorphism, susceptibility, urinary system cancer