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J Cancer 2016; 7(14):2035-2044. doi:10.7150/jca.15200 This issue Cite

Research Paper

Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways

Sami Benzina1,2, Jason Harquail1,2, Roxann Guerrette1,2, Pierre O'Brien1,2, Stéphanie Jean1,2, Nicolas Crapoulet1, Gilles A. Robichaud1,2✉

1. Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
2. Atlantic Cancer Research Institute, Moncton, NB, Canada E1C 8X3.

✉ Corresponding author: Gilles A. Robichaud, Université de Moncton, Moncton, NB, Canada, E1A 3E9. gilles.robichaudca; Tel: (506)858-4320; Fax: (506)858-4541.

Citation:
Benzina S, Harquail J, Guerrette R, O'Brien P, Jean S, Crapoulet N, Robichaud GA. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J Cancer 2016; 7(14):2035-2044. doi:10.7150/jca.15200. https://www.jcancer.org/v07p2035.htm
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Abstract

The study of genetic factors regulating breast cancer malignancy is a top priority to mitigate the morbidity and mortality associated with this disease. One of these factors, Pax-5, modulates cancer aggressiveness through the regulation of various components of the epithelial to mesenchymal transitioning (EMT) process. We have previously reported that Pax-5 expression profiles in cancer tissues inversely correlate with those of the Focal Adhesion Kinase (FAK), a potent activator of breast cancer malignancy. In this study, we set out to elucidate the molecular and regulatory relationship between Pax-5 and FAK in breast cancer processes. Interestingly, we found that Pax-5 mediated suppression of breast cancer cell migration is dependent of FAK activity. Our mechanistic examination revealed that Pax-5 inhibits FAK expression and activation. We also demonstrate that Pax-5 is a potent modulator of FAK repressors (p53 and miR-135b) and activator (NFκB) which results in the overall suppression of FAK-mediated signaling cascades. Altogether, our findings bring more insight to the molecular triggers regulating phenotypic transitioning process and signaling cascades leading to breast cancer progression.

Keywords: FAK, Pax-5, Breast cancer, EMT-MET, NFκB, migration, metastasis.

Citation styles

APA
Benzina, S., Harquail, J., Guerrette, R., O'Brien, P., Jean, S., Crapoulet, N., Robichaud, G.A. (2016). Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. Journal of Cancer, 7(14), 2035-2044. https://doi.org/10.7150/jca.15200.

ACS
Benzina, S.; Harquail, J.; Guerrette, R.; O'Brien, P.; Jean, S.; Crapoulet, N.; Robichaud, G.A. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J. Cancer 2016, 7 (14), 2035-2044. DOI: 10.7150/jca.15200.

NLM
Benzina S, Harquail J, Guerrette R, O'Brien P, Jean S, Crapoulet N, Robichaud GA. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J Cancer 2016; 7(14):2035-2044. doi:10.7150/jca.15200. https://www.jcancer.org/v07p2035.htm

CSE
Benzina S, Harquail J, Guerrette R, O'Brien P, Jean S, Crapoulet N, Robichaud GA. 2016. Breast Cancer Malignant Processes are Regulated by Pax-5 Through the Disruption of FAK Signaling Pathways. J Cancer. 7(14):2035-2044.

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