J Cancer 2016; 7(14):2045-2051. doi:10.7150/jca.15323 This issue


An Overview of Genetic Changes and Risk of Pancreatic Ductal Adenocarcinoma

Agnieszka K. Sarnecka1,2✉, Malgorzata Zagozda1,2, Marek Durlik1,2

1. Department of Surgical Research & Transplantology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
2. Central Clinical Hospital, Ministry of Internal Affairs, Warsaw, Poland.

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Sarnecka AK, Zagozda M, Durlik M. An Overview of Genetic Changes and Risk of Pancreatic Ductal Adenocarcinoma. J Cancer 2016; 7(14):2045-2051. doi:10.7150/jca.15323. Available from https://www.jcancer.org/v07p2045.htm

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The pancreatic carcinoma is a leading cause of death in cancer carriers worldwide. The early diagnostic is difficult due to late stage during diagnosis, lack of characteristic symptoms and also multifactor basis. In cancer development take part both, environmental and genetic factors, alone or in conjunction with each other. The nonspecific biomarkers of cancers are a reason for the search for more accurate factors which allow for fast and personalized diagnostics. Some of cancers have identified molecular (metabolic, biochemical or genetic) markers but in most cases the only clue is patient`s interview and abnormal levels of organ functions markers.

Possible genetic basis of cancer suggests to widen studies on connection between environmental factors with both, nuclear and mitochondrial, genes changes.

Keywords: pancreatic carcinoma, polymorphism.