Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma

Zhang, Qiao; Yi, Xiaojia; Yang, Zhe; Han, Qiaoqiao; Di, Xuesong; Chen, Fufei; Wang, Yanling; Yi, Zihan; Kuang, Yingmin; Zhu, Yuechun

doi:10.7150/jca.16858

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J Cancer 2017; 8(4):665-673. doi:10.7150/jca.16858 This issue Cite

Research Paper

Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma

Qiao Zhang^1*, Xiaojia Yi^2*, Zhe Yang^3*, Qiaoqiao Han¹, Xuesong Di⁴, Fufei Chen⁴, Yanling Wang¹, Zihan Yi¹, Yingmin Kuang^4✉, Yuechun Zhu^{1 ✉}

1. Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, Yunnan, China;
2. Department of pathology, The Second Affiliated Hospital of Kunming Medical University, Yunnan, China;
3. Department of pathology, The First Affiliated Hospital of Kunming Medical University, Yunnan, China;
4. Department of organ transplantation, The First Affiliated Hospital of Kunming Medical University, Yunnan, China.
* Equal contributors

✉ Corresponding authors: Yuechun Zhu, Professor, Biochemistry and Molecular Biology, School of Basic Medical Sciences, Kunming Medical University, No.1168 Yuhua Road, Chenggong District, Kunming 650500, Yunnan Province, China. E-mail: zhuyuechun200911 More

Citation:

Zhang Q, Yi X, Yang Z, Han Q, Di X, Chen F, Wang Y, Yi Z, Kuang Y, Zhu Y. Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma. J Cancer 2017; 8(4):665-673. doi:10.7150/jca.16858. https://www.jcancer.org/v08p0665.htm

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Abstract

Glucose-6-phosphate dehydrogenase (G6PD) participates in glucose metabolism and it acts as the rate-limiting enzyme of the pentose phosphate pathway (PPP). Recently, G6PD dysregulation has been found in a variety of human cancers. Through analyzing published data in The Cancer Genome Atlas (TCGA), our pilot study indicated that G6PD mRNA expression was significantly higher in advanced Fuhrman grade in clear cell renal cell carcinoma (ccRCC). These clues promoted us to further evaluate the expression profile of G6PD and its prognostic impact in patients with ccRCC. In this study, G6PD expression levels were analyzed in 149 human ccRCC and normal tissues using immunohistochemistry. The results showed that compared with that in the normal renal samples, G6PD was found highly expressed in 51.0% of ccRCC (p<0.05). High expression of G6PD was significantly correlated to tumor extent, lymph node metastasis, Fuhrman grade, and TNM stage of ccRCC (all p<0.05). Moreover, positive G6PD expression was associated with poorer overall survival in ccRCC (p<0.001). In Cox regression analyses, high expression of G6PD also could be an independent prognostic factor for overall survival in ccRCC (p=0.007). This study suggests that overexpression of G6PD is associated with advanced disease status and therefore may become an important prognosticator for poor outcomes in ccRCC, as well as a potential therapeutic target for developing effective treatment modalities.

Keywords: glucose-6-phosphate dehydrogenase, renal cell carcinoma, TCGA data mining, immunohistochemistry, prognosis biomarker

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APA

Zhang, Q., Yi, X., Yang, Z., Han, Q., Di, X., Chen, F., Wang, Y., Yi, Z., Kuang, Y., Zhu, Y. (2017). Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma. Journal of Cancer, 8(4), 665-673. https://doi.org/10.7150/jca.16858.

ACS

Zhang, Q.; Yi, X.; Yang, Z.; Han, Q.; Di, X.; Chen, F.; Wang, Y.; Yi, Z.; Kuang, Y.; Zhu, Y. Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma. J. Cancer 2017, 8 (4), 665-673. DOI: 10.7150/jca.16858.

NLM

CSE

Zhang Q, Yi X, Yang Z, Han Q, Di X, Chen F, Wang Y, Yi Z, Kuang Y, Zhu Y. 2017. Overexpression of G6PD Represents a Potential Prognostic Factor in Clear Cell Renal Cell Carcinoma. J Cancer. 8(4):665-673.

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