J Cancer 2018; 9(10):1765-1772. doi:10.7150/jca.24573 This issue
1. Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine
2. Department of Nasopharyngeal Carcinoma; Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
3. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
4. Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
#These authors contributed equally to this article.
*The senior authors contributed equally to this work.
Background: To assess the prognosis of neck residue nasopharyngeal carcinoma (NPC) patients and the efficacy of neck dissection in the treatment of these patients.
Methods: We recruited 68 neck residue NPC patients. For each neck residue patient we had three matched NPC patients without neck residue as controls (n = 204). The primary endpoint was progression-free survival (PFS). The Cox proportional hazards model was used to calculate hazard ratios (HRs) with 95% confidence intervals (CIs), and multivariable analysis was used to test the independent statistical significance of NPC patients.
Results: Compared to controls, the neck residue patients showed significantly lower 3-year PFS (46.7% vs. 87.6%; P < 0.001). Multivariable analysis showed that neck residue was an independent prognostic factor for PFS.
Conclusions: NPC patients who had pathologically proven neck residue are associated with poor prognosis. Management with neck dissection alone seems not to be sufficient for these patients.
Keywords: nasopharyngeal carcinoma, neck residue, prognosis, neck dissection, case-cohort study