The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma

Wang, Yan; He, Sha-Sha; Cai, Xiu-yu; Chen, Hai-Yang; Yang, Xing-Li; Lu, Li-Xia; Chen, Yong

doi:10.7150/jca.24838

International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

Nanotheranostics

open access Global reach, higher impact

Full Text | PDF

J Cancer 2018; 9(13):2295-2301. doi:10.7150/jca.24838 This issue Cite

Research Paper

The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma

Yan Wang^*1, Sha-Sha He^*2, Xiu-yu Cai³, Hai-Yang Chen⁴, Xing-Li Yang², Li-Xia Lu^2✉, Yong Chen^1✉

1. Department of Radiation Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510060, PR China.
2. Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong 510060, PR China; Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong 510060, PR China.
3. Department of VIP region, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong 510060, PR China.
4. Department of Radiation Oncology, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*These authors contributed equally to this work.

Citation:

Wang Y, He SS, Cai Xy, Chen HY, Yang XL, Lu LX, Chen Y. The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma. J Cancer 2018; 9(13):2295-2301. doi:10.7150/jca.24838. https://www.jcancer.org/v09p2295.htm

Other styles

Abstract

Background: A novel inflammation-and nutrition-based scoring system based on red blood cell distribution width and body mass index (COR-BMI) has prognostic value in nasopharyngeal carcinoma (NPC). Here, we assessed the prognostic value of COR-BMI in NPC.

Methods: Retrospective study of 2,318 patients with non-metastatic NPC treated at Sun Yat-sen University Cancer Center was conducted. Patients were stratified into three groups using the COR-BMI score, which is based on two objective and easily measurable parameters: red blood cell distribution width (RDW) and body mass index (BMI). Kaplan-Meier survival analyses were used to compare groups; multivariate Cox proportional models were used to calculate overall survival (OS) and disease-free survival (DFS).

Results: Four-year overall survival (OS) rates were 88.7%, 84.5%, and 71.4% for patients with COR-BMI scores of 0, 1, and 2 respectively (P = 0.006). Multivariate Cox proportional hazard analysis revealed COR-BMI was an independent predictor of OS (HR for COR-BMI 1: 1.239, 95% CI: 1.012-1.590; HR for COR-BMI 2: 2.367, 95% CI: 1.311-4.274, P = 0.013), but not DFS (P = 0.482). In subgroup analysis of metastatic NPC, OS rates decreased as COR-BMI increased. In patients with a COR-BMI score of 1, radiotherapy plus chemotherapy led to better OS than radiotherapy alone.

Conclusions: COR-BMI may serve as an indicator of poor prognosis in both NPC and metastatic NPC. Radiotherapy plus chemotherapy may benefit patients with a COR-BMI score of 1.

Keywords: Nasopharyngeal carcinoma, red blood cell distribution width, body mass index, prognosis

Citation styles

APA

Wang, Y., He, S.S., Cai, X.y., Chen, H.Y., Yang, X.L., Lu, L.X., Chen, Y. (2018). The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma. Journal of Cancer, 9(13), 2295-2301. https://doi.org/10.7150/jca.24838.

ACS

Wang, Y.; He, S.S.; Cai, X.y.; Chen, H.Y.; Yang, X.L.; Lu, L.X.; Chen, Y. The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma. J. Cancer 2018, 9 (13), 2295-2301. DOI: 10.7150/jca.24838.

NLM

CSE

Wang Y, He SS, Cai Xy, Chen HY, Yang XL, Lu LX, Chen Y. 2018. The Novel Prognostic Score Combining Red Blood Cell Distribution Width and Body Mass Index (COR-BMI) Has Prognostic Impact for Survival Outcomes in Nasopharyngeal Carcinoma. J Cancer. 9(13):2295-2301.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.