Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Liao, Xiwen; Liu, Xiaoguang; Yang, Chengkun; Wang, Xiangkun; Yu, Tingdong; Han, Chuangye; Huang, Ketuan; Zhu, Guangzhi; Su, Hao; Qin, Wei; Huang, Rui; Yu, Long; Deng, Jianlong; Zeng, Xianmin; Ye, Xinping; Peng, Tao

doi:10.7150/jca.25221

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International Journal of Biological Sciences

International Journal of Medical Sciences

Theranostics

Journal of Genomics

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J Cancer 2018; 9(13):2357-2373. doi:10.7150/jca.25221 This issue Cite

Research Paper

Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma

Xiwen Liao¹, Xiaoguang Liu^1,2, Chengkun Yang¹, Xiangkun Wang¹, Tingdong Yu¹, Chuangye Han¹, Ketuan Huang¹, Guangzhi Zhu¹, Hao Su¹, Wei Qin¹, Rui Huang³, Long Yu^1,4, Jianlong Deng^1,5, Xianmin Zeng¹, Xinping Ye¹, Tao Peng^1✉

1. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
2. Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, 524001, Guangdong Province, People's Republic of China.
3. Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi, China.
4. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, Henan, China.
5. Department of Hepatobiliary Surgery, The Sixth Affiliated Hospital of Guangxi Medical University, Yulin, 537000, Guangxi, China.

Citation:

Liao X, Liu X, Yang C, Wang X, Yu T, Han C, Huang K, Zhu G, Su H, Qin W, Huang R, Yu L, Deng J, Zeng X, Ye X, Peng T. Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma. J Cancer 2018; 9(13):2357-2373. doi:10.7150/jca.25221. https://www.jcancer.org/v09p2357.htm

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Abstract

Background: The aim of the present study was to identify diagnostic and prognostic values of minichromosome maintenance (MCM) gene expression in patients with hepatocellular carcinoma (HCC).

Methods: The biological function of the MCM genes were investigated by bioinformatics analysis. The diagnostic and prognostic values of the MCM genes were investigated by using the data of HCC patients from the GSE14520 and The Cancer Genome Atlas (TCGA) databases.

Results: Bioinformatics analysis of the MCM genes substantiated that MCM2-7 genes were significantly enriched in DNA replication and cell cycle, and co-expressed with each other. These genes also co-expressed in HCC tumor tissue in both the GSE14520 and TCGA cohort. We also observed that the expression of the MCM2-7 genes was increased in tumor tissue, and diagnostic receiver operating characteristic analysis of MCM2-7 indicated that these genes could serve as sensitive diagnostic markers in HCC. Survival analysis in the GSE14520 cohort suggested that expression of MCM2, MCM4, MCM5, and MCM6 were significantly associated with hepatitis B virus-related HCC overall survival (OS). However, none of the MCM genes were associated with recurrence-free survival in the GSE14520 cohort. The validation cohort of TCGA suggested that the expression of MCM2, MCM6, and MCM7 were significantly correlated with HCC OS.

Conclusion: Our study indicated that MCM2-7 genes may be potential diagnostic biomarkers in patients with HCC. Among them, MCM2 and MCM6 may serve as potential prognostic biomarkers for HCC.

Keywords: minichromosome maintenance, mRNA, hepatocellular carcinoma, prognosis, diagnosis

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APA

Liao, X., Liu, X., Yang, C., Wang, X., Yu, T., Han, C., Huang, K., Zhu, G., Su, H., Qin, W., Huang, R., Yu, L., Deng, J., Zeng, X., Ye, X., Peng, T. (2018). Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma. Journal of Cancer, 9(13), 2357-2373. https://doi.org/10.7150/jca.25221.

ACS

Liao, X.; Liu, X.; Yang, C.; Wang, X.; Yu, T.; Han, C.; Huang, K.; Zhu, G.; Su, H.; Qin, W.; Huang, R.; Yu, L.; Deng, J.; Zeng, X.; Ye, X.; Peng, T. Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma. J. Cancer 2018, 9 (13), 2357-2373. DOI: 10.7150/jca.25221.

NLM

CSE

Liao X, Liu X, Yang C, Wang X, Yu T, Han C, Huang K, Zhu G, Su H, Qin W, Huang R, Yu L, Deng J, Zeng X, Ye X, Peng T. 2018. Distinct Diagnostic and Prognostic Values of Minichromosome Maintenance Gene Expression in Patients with Hepatocellular Carcinoma. J Cancer. 9(13):2357-2373.

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