J Cancer 2018; 9(22):4179-4186. doi:10.7150/jca.27483 This issue

Research Paper

Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis

Wenyi Wang1,2#, Shaopu Hu1,2#, Junli Chang1,2, Hongfeng Ruan1,2, Wenlan Zhi1,2, Xiaobo Wang1,2, Qi Shi1,2, Yongjun Wang1,2, Yanping Yang1,2✉

1. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032China;
2. Key laboratory of theory and therapy of muscles and bones, Ministry of Education, Shanghai200032, China.
# Wenyi Wang and Shaopu Hu contributed equally to this work.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
Wang W, Hu S, Chang J, Ruan H, Zhi W, Wang X, Shi Q, Wang Y, Yang Y. Down-Regulated microRNA-34a Expression as a Prognostic Marker for Poor Osteosarcoma in Mice: A Systematic Review and Meta-Analysis. J Cancer 2018; 9(22):4179-4186. doi:10.7150/jca.27483. Available from https://www.jcancer.org/v09p4179.htm

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Background: In children and adolescents, osteosarcomais the most common malignant bone tumor with a high mortality rate. New therapeutic strategies are urgent to be explored. Studies have proven that microRNAs (miRNAs) in malignant tumors often appear dysregulation, this provides a direction for exploring the new therapeutic strategies for cancers. The aim of this meta-analysis is to summarize and analyze whethermicroRNA-34a(miRNA-34a) could be a prognostic marker for osteosarcoma in mice.

Methods: We searched PubMed, Web of Science, Embase, Wan Fang Database, China Knowledge Resource Integrated Database, VIP Database, and SinoMed since their initiation date to January 24, 2018. After screening based on inclusion and exclusion criteria, eight articles were included for the final analysis.

Results: Our results showed that tumor volume and tumor weight were inhibited by restoring the down-regulated expression of miRNA-34a in the xenograft mouse models.

Conclusions: Down-regulated miRNA-34a expression is a prognostic marker for poor osteosarcoma. We should be more committed to investigate the clinical significance of miRNA-34a in osteosarcoma patients.

Keywords: microRNA-34a, osteosarcoma, prognosis, meta-analysis, mice