J Cancer 2019; 10(8):1800-1807. doi:10.7150/jca.29889 This issue

Research Paper

CUEDC2 Contributes to Cisplatin-Based Chemotherapy Resistance in Ovarian Serious Carcinoma by Regulating p38 MAPK Signaling

Aichun Wang1,2*, Jinhang Li1*, Tao Zhou3, Tao Li3, Hong Cai3, Huaiyin Shi1✉, Aijun Liu1✉

1. Department of Pathology, People's Liberation Army General Hospital, Beijing, 100853, China
2. Department of Pathology, Haidian Maternal & Children Health Hospital, Beijing, 100080, China
3. National Center of Biomedical Analysis, Institute of Basic Medical Sciences, Beijing, 100850, China
*These authors contributed equally to this project.

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Wang A, Li J, Zhou T, Li T, Cai H, Shi H, Liu A. CUEDC2 Contributes to Cisplatin-Based Chemotherapy Resistance in Ovarian Serious Carcinoma by Regulating p38 MAPK Signaling. J Cancer 2019; 10(8):1800-1807. doi:10.7150/jca.29889. Available from https://www.jcancer.org/v10p1800.htm

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Chemoresistance remains an obstacle to the successful treatment of ovarian carcinoma. CUE domain-containing 2 (CUEDC2) plays critical roles in tumor genesis and overexpresses in many solid cancers, including ovarian serous carcinoma. In previous study, we found that overexpression of CUEDC2 might be a promising biomarker to evaluate the progression and to predict likely relapse of serous ovarian carcinoma. In present study, we found that higher expression of CUEDC2 was associated with higher resistance to cisplatin. The overall survival (OS) and disease-free survival time (DFS) of patients with cisplatin resistant was shorter than that of those with cisplatin sensitive, respectively, and the cisplatin sensitivity was independent predictor of a shorter OS time and DFS time. Knockdown of CUEDC2 by small interfering RNA enhanced the cisplatin sensitivity of serous ovarian carcinoma cells in SKOV3 cell lines. Furthermore, the phosphorylation of p38 MAPK were obviously increased after CUEDC2 knockdown, while p38 MAPK signaling contributes to cell growth and cell apoptosis. Our data suggest that CUEDC2 takes part in cisplatin-based chemotherapy resistance by regulating p38 MAPK signaling. And CUEDC2 is a promising biomarker and therapeutic target of cisplatin resistance in ovarian serous carcinoma.

Keywords: CUEDC2, ovarian carcinoma, chemoresistance, cisplatin, p38 MAPK