J Cancer 2019; 10(10):2205-2219. doi:10.7150/jca.30612 This issue Cite

Research Paper

The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma

Qiaoqi Wang1*, Fuqiang Pan1*, Sizhu Li2, Rui Huang3, Xiangkun Wang4, Shijun Wang5, Xiwen Liao4, Dong Li1✉, Liming Zhang1✉

1. Department of Medical Cosmetology, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China
2. Department of Medical Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China
3. Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China
4. Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People's Republic of China
5. Department of Colorectal and Anal Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, People's Republic of China
*These authors contributed to the work equally and should be regarded as co-first authors

Citation:
Wang Q, Pan F, Li S, Huang R, Wang X, Wang S, Liao X, Li D, Zhang L. The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma. J Cancer 2019; 10(10):2205-2219. doi:10.7150/jca.30612. https://www.jcancer.org/v10p2205.htm
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Abstract

Background: The functional significance of the proteasome activator subunit (PSME) gene family in the pathogenesis of skin cutaneous melanoma (SKCM) remains to be elucidated.

Materials and methods: Clinical data for patients with SKCM, including expression levels of PSME genes, were extracted from TCGA. GO term and KEGG pathway enrichment analyses were performed. Correlations between the expression levels of PSME genes in SKCM were evaluated with the Pearson correlation coefficient. Functional and enrichment analyses were conducted using DAVID. Univariate and multivariate survival analyses adjusted by Cox regression were used to construct a prognostic signature. The mechanisms underlying the association between PSME gene expression and overall survival (OS) were explored with gene set enrichment analysis. Joint-effects survival analysis was performed to evaluate the clinical value of the prognostic signature.

Results: The median expression levels of PSME1, PSME2 and PSME3 were significantly higher in SKCM than in normal skin. PSME1, PSME2, and PSME3 were significantly enriched in several biological processes and pathways including cell adhesion, adherens junction organization, regulation of autophagy, cellular protein localization, the cell cycle, apoptosis, and the Wnt and NF-κB pathways. High expression levels of PSME1 and PSME2 combined with a low expression level of PSME3 was associated with favorable OS.

Conclusion: Knowledge of the expression levels of the PSME gene family could provide a sensitive strategy for predicting prognosis in SKCM.

Keywords: Proteasome activator subunit, melanoma, prognosis, nomogram, overall survival


Citation styles

APA
Wang, Q., Pan, F., Li, S., Huang, R., Wang, X., Wang, S., Liao, X., Li, D., Zhang, L. (2019). The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma. Journal of Cancer, 10(10), 2205-2219. https://doi.org/10.7150/jca.30612.

ACS
Wang, Q.; Pan, F.; Li, S.; Huang, R.; Wang, X.; Wang, S.; Liao, X.; Li, D.; Zhang, L. The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma. J. Cancer 2019, 10 (10), 2205-2219. DOI: 10.7150/jca.30612.

NLM
Wang Q, Pan F, Li S, Huang R, Wang X, Wang S, Liao X, Li D, Zhang L. The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma. J Cancer 2019; 10(10):2205-2219. doi:10.7150/jca.30612. https://www.jcancer.org/v10p2205.htm

CSE
Wang Q, Pan F, Li S, Huang R, Wang X, Wang S, Liao X, Li D, Zhang L. 2019. The prognostic value of the proteasome activator subunit gene family in skin cutaneous melanoma. J Cancer. 10(10):2205-2219.

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