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J Cancer 2019; 10(13):2961-2968. doi:10.7150/jca.31004 This issue Cite

Research Paper

Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway

Mingjun Yu1,2,3, Shijia Yu4, Wei Gong5, Duo Chen1,2, Junhong Guan1,2, Yunhui Liu1,2,3✉

1. Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China
2. Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang 110004, People's Republic of China
3. Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang 110004, People's Republic of China
4. Department of Neurology, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China
5. Exprimental Research center, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China

✉ Corresponding author: Yunhui Liu, Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang 110004, People's Republic of China. Telephone number: +86 024 96615-36111; Fax number: +86 024 2295 8989; Email: liuyunhui17c More

Citation:
Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. J Cancer 2019; 10(13):2961-2968. doi:10.7150/jca.31004. https://www.jcancer.org/v10p2961.htm
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Abstract

LncRNAs have been proved to be involved in the promotion of glioma cell malignant development. However, the exact roles and molecular mechanisms of linc01023 in glioma remain blurred. In this study, we confirm linc01023 is up-regulated in glioma tissues and cell lines. In addition, elevated linc01023 expression indicates shorter survival times in patients with glioma. Moreover, loss-of-function studies reveal that restoration of linc01023 restrains glioma cell proliferation, migration and invasion by regulating IGF1R/AKT pathway in vitro and in vivo. Collectively, the study indicates that linc01023 plays an oncogenic role in glioma through activation of IGF1R/AKT signal pathway, and it could be a candidate therapeutic target.

Keywords: Glioma, Prognosis, Linc01023, IGF1R, AKT

Citation styles

APA
Yu, M., Yu, S., Gong, W., Chen, D., Guan, J., Liu, Y. (2019). Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. Journal of Cancer, 10(13), 2961-2968. https://doi.org/10.7150/jca.31004.

ACS
Yu, M.; Yu, S.; Gong, W.; Chen, D.; Guan, J.; Liu, Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. J. Cancer 2019, 10 (13), 2961-2968. DOI: 10.7150/jca.31004.

NLM
Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. J Cancer 2019; 10(13):2961-2968. doi:10.7150/jca.31004. https://www.jcancer.org/v10p2961.htm

CSE
Yu M, Yu S, Gong W, Chen D, Guan J, Liu Y. 2019. Knockdown of linc01023 restrains glioma proliferation, migration and invasion by regulating IGF-1R/AKT pathway. J Cancer. 10(13):2961-2968.

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