J Cancer 2019; 10(17):3893-3898. doi:10.7150/jca.31362 This issue Cite

Research Paper

CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665

Ning Bai1, Eming Peng2, Fada Xia1, Dong Wang1, Xiaogang Li1✉, Xinying Li1✉

1. Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China
2. Department of XIMC Outpatient, Xiangya Hospital, Central South University, Changsha, China

Citation:
Bai N, Peng E, Xia F, Wang D, Li X, Li X. CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. J Cancer 2019; 10(17):3893-3898. doi:10.7150/jca.31362. https://www.jcancer.org/v10p3893.htm
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Abstract

Background: Numerous studies have shown that circular RNAs (circRNAs) play vital roles in tumor progression. However, how circRNAs function in hepatocellular cancer (HCC) remains mostly unclear.

Methods: We analyzed HCC circRNA expression via a microarray, and the expression of an upregulated circRNA, circABCC2, was detected. We next explored the function of circABCC2 in HCC via a series of experiments. We performed RNA immunoprecipitation (RIP) and luciferase assays to explore the competing endogenous RNA (ceRNA) function of circABCC2 in HCC.

Results: qRT-PCR verified that circABCC2 was overexpressed in HCC. Inhibition of circABCC2 suppressed HCC cell proliferation and invasion, but promoted apoptosis. Luciferase assays and RIP showed that circABCC2 and ABCC2 could directly bind to miR-665 and that circABCC2 could regulate ABCC2 expression by sponging miR-665.

Conclusions: In summary, circABCC2 regulates ABCC2 expression and HCC progression by sponging miR-665. circABCC2 could be used as a biomarker and therapeutic target in HCC.

Keywords: hepatocellular cancer, circular RNAs, miR-665, ABCC2, competitive endogenous RNAs


Citation styles

APA
Bai, N., Peng, E., Xia, F., Wang, D., Li, X., Li, X. (2019). CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. Journal of Cancer, 10(17), 3893-3898. https://doi.org/10.7150/jca.31362.

ACS
Bai, N.; Peng, E.; Xia, F.; Wang, D.; Li, X.; Li, X. CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. J. Cancer 2019, 10 (17), 3893-3898. DOI: 10.7150/jca.31362.

NLM
Bai N, Peng E, Xia F, Wang D, Li X, Li X. CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. J Cancer 2019; 10(17):3893-3898. doi:10.7150/jca.31362. https://www.jcancer.org/v10p3893.htm

CSE
Bai N, Peng E, Xia F, Wang D, Li X, Li X. 2019. CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665. J Cancer. 10(17):3893-3898.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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