J Cancer 2019; 10(17):4096-4105. doi:10.7150/jca.31173 This issue

Research Paper

Association of Preoperative Plasma D-dimmer and Fibrinogen and Renal Cell Carcinoma Outcome

Xiaobo He1,2#, Tao Huang3#, Yunfei Xue4#, Meng Zhang5, Qiaodan Liu2, Yongqiang Wang1,6, Kai Yao1✉, Shengjie Guo1✉

1. Department of Urology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China.
2. Department of Medical Oncology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, China.
3. Department of Urology, Shunde People's Hospital, Southern Medical University, Guangdong, China.
4. Vascular Surgery Center, Fuwai Hospital, Chinese Academy of Medicine Sciences Beijing, China.
5. B.M. Urinary Surgery, China-Japan Friendship Hospital, Beijing, China.
6. Department of Biochemistry and Molecular Medicine, school of Medicine, University of California Davis, Sacramento, California, USA.
# These authors contributed equally to this work.

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Citation:
He X, Huang T, Xue Y, Zhang M, Liu Q, Wang Y, Yao K, Guo S. Association of Preoperative Plasma D-dimmer and Fibrinogen and Renal Cell Carcinoma Outcome. J Cancer 2019; 10(17):4096-4105. doi:10.7150/jca.31173. Available from https://www.jcancer.org/v10p4096.htm

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Abstract

Background: the plasma D-dimer and fibrinogen which are indicators of coagulation-fibrinolysis system has been reported to be associated with survival in several types of cancers, including RCC. The aim of our study was to assess the prognostic significance of preoperative plasma D-dimer and fibrinogen levels in RCC patients.

Methods: Data from 449 patients with RCC were assessed retrospectively. Cutoff value for plasma D-dimer and fibrinogen were tested by the standardized cutoff-finder algorithm. Overall survival (OS) and disease-free survival (DFS) were evaluated using the Kaplan-Meier method. Univariate and Multivariate Cox regression models were further applied for two end points.

Results: Multivariate analysis identified increased plasma D-dimer and fibrinogen as independent prognostic factors for OS (D-dimer, P=0.017; Fibrinogen, P=0.049) and DFS (D-dimer, P=0.038; Fibrinogen, P<0.001). Moreover, all the patients were stratified using these two factors in the following ways: (1) Low risk: both level of plasma D-dimer and fibrinogen were no more than cutoff value. (2) Intermediate risk: neither low risk nor high risk, (3) high risk: both level of plasma D-dimer and fibrinogen were higher than cutoff value. This model showed significant predictive power for OS and DFS.

Conclusion: preoperatively elevated D-dimer and fibrinogen can be regard as independent predictors for patients' prognosis in RCC. Combining both plasma D-dimer and fibrinogen can improve the prognostic accuracy and easy accessibility in clinical practice.

Keywords: renal cell cancer, coagulation-fibrinolysis system, fibrinogen, D-dimer, prognosis.