HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma

Dai, Bo-Wen; Yang, Zhi-Min; Deng, Ping; Chen, Yan-Rong; He, Zhi-Jing; Yang, Xi; Zhang, Sheng; Wu, Han-Jiang; Ren, Zhen-Hu

doi:10.7150/jca.30645

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J Cancer 2019; 10(19):4540-4551. doi:10.7150/jca.30645 This issue Cite

Research Paper

HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma

Bo-Wen Dai^1*, Zhi-Min Yang^1*, Ping Deng^2*, Yan-Rong Chen¹, Zhi-Jing He¹, Xi Yang³, Sheng Zhang^1✉, Han-Jiang Wu^1✉, Zhen-Hu Ren^3✉

1. Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
2. Department of Occupational Health, Third Military Medical University, Chongqing, China
3. Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
* These authors contributed equally to this work

✉ Corresponding authors: Zhen-Hu Ren, Department of Oral Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. E-mail: renzhenhusjtu.edu.cn Han-Jiang Wu, Department of More

Citation:

Dai BW, Yang ZM, Deng P, Chen YR, He ZJ, Yang X, Zhang S, Wu HJ, Ren ZH. HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. J Cancer 2019; 10(19):4540-4551. doi:10.7150/jca.30645. https://www.jcancer.org/v10p4540.htm

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Abstract

As a master regulator of embryonic morphogenesis, homeodomain-containing gene 10 (HOXC10) has been found to promote progression of human cancers and indicate poor survival outcome. Therefore, we concentrate on elucidating the role of HOXC10 in progression of oral squamous cell carcinoma (OSCC). In our study, the expression of HOXC10 was significantly increased in human OSCC samples and was significantly correlated with TNM stage and lymph node metastasis. Upregulation of HOXC10 indicated a poor overall survival of OSCC patients according to the Kaplan-Meier survival curves. Furthermore, HOXC10-knockdown dramatically suppressed migration, invasion, and expression of N-Cadherin, Vimentin and Snail, as well as increased E-cadherin level both in vivo and in vitro. Bioinformatics and cellular study further confirmed that HOXC10 may promote invasion and migration of OSCC cells by regulating the WNT/epithelial-mesenchymal transition (EMT) signaling pathway. These findings suggest that HOXC10 plays a pivotal role in the metastasis of OSCC and highlight its usefulness as a potential prognostic marker or therapeutic target in human OSCC.

Keywords: HOXC10, WNT10B, oral squamous cell carcinoma, epithelial-mesenchymal transition

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APA

Dai, B.W., Yang, Z.M., Deng, P., Chen, Y.R., He, Z.J., Yang, X., Zhang, S., Wu, H.J., Ren, Z.H. (2019). HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. Journal of Cancer, 10(19), 4540-4551. https://doi.org/10.7150/jca.30645.

ACS

Dai, B.W.; Yang, Z.M.; Deng, P.; Chen, Y.R.; He, Z.J.; Yang, X.; Zhang, S.; Wu, H.J.; Ren, Z.H. HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. J. Cancer 2019, 10 (19), 4540-4551. DOI: 10.7150/jca.30645.

NLM

CSE

Dai BW, Yang ZM, Deng P, Chen YR, He ZJ, Yang X, Zhang S, Wu HJ, Ren ZH. 2019. HOXC10 promotes migration and invasion via the WNT-EMT signaling pathway in oral squamous cell carcinoma. J Cancer. 10(19):4540-4551.

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