J Cancer 2020; 11(1):208-212. doi:10.7150/jca.36513 This issue

Research Paper

Frequency and Clinical Characteristics of Unselected Korean Gastric Cancer Patients with a Germline CDH1 V832M Mutation

Saeam Shin1*, Yoonjung Kim1*, Jin Kyung Lee2,3✉, Kyung-A Lee1✉

1. Department of Laboratory Medicine, Yonsei University College of Medicine, Seoul, Korea;
2. Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea;
3. KIRAMS Radiation Biobank, Korea Institute of Radiological and Medical Sciences, Seoul, Korea.
*These authors contributed equally to this work.

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Citation:
Shin S, Kim Y, Lee JK, Lee KA. Frequency and Clinical Characteristics of Unselected Korean Gastric Cancer Patients with a Germline CDH1 V832M Mutation. J Cancer 2020; 11(1):208-212. doi:10.7150/jca.36513. Available from https://www.jcancer.org/v11p0208.htm

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Abstract

Background: Germline mutations in CDH1 are associated with hereditary and early onset- diffuse gastric cancer. However, the frequency of CDH1 germline mutation in unselected gastric cancer cases is not well established.

Aim: The aim of this study was to investigate the frequency and clinical characteristics of germline CDH1 V832M mutation carriers in unselected Korean gastric cancer cases.

Methods: Direct sequencing was performed to determine the presence of CDH1 V832M in 305 unselected Korean gastric cancer patients. Lauren's histologic type, family history of gastric cancer, and age of cancer diagnosis were compared between V832M carriers and non-carriers.

Results: In the study population, seven gastric cancer patients (7/305, 2.29%) were found to have the CDH1 V832M mutation. The CDH1 V832M mutation carrier state was not significantly associated with phenotypes including Lauren's histologic type, family history of gastric cancer, age of cancer diagnosis, and other cancer history in a patient.

Conclusion: This study demonstrates that the germline CDH1 V832M mutation is common in sporadic, late onset, and intestinal type gastric cancer as well as familial, early onset, and diffuse type gastric cancer. Our finding suggests that guidelines for managing CDH1 mutation carriers should be refined through additional data on penetration according to CDH1 mutation type in sporadic cases.

Keywords: CDH1, E-cadherin, gastric cancer, hereditary gastric cancer, germline mutation