J Cancer 2020; 11(7):1949-1958. doi:10.7150/jca.38847 This issue

Research Paper

Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway

Ruicheng Fan1,2, Heng Wang3, Liyuan Zhang3, Teng Ma1, Yanping Tian1✉, Hongli Li1✉

1. Department of Histology and Embryology, College of Basic Medicine, Army Medical University, Chongqing, China.
2. Battalion 3, College of Basic Medicine, Army Medical University, Chongqing, China.
3. Battalion 4, College of Basic Medicine, Army Medical University, Chongqing, China.

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Citation:
Fan R, Wang H, Zhang L, Ma T, Tian Y, Li H. Nanocrystallized Oleanolic Acid Better Inhibits Proliferation, Migration and Invasion in Intracranial Glioma via Caspase-3 Pathway. J Cancer 2020; 11(7):1949-1958. doi:10.7150/jca.38847. Available from https://www.jcancer.org/v11p1949.htm

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Abstract

Glioma associates with high malignancy and poor prognosis for traditional treatment. Oleanolic acid (OA) has been confirmed to have an inhibitory effect on different kinds of tumors, while accompanying with low efficiency because of its large molecular mass and low solubility. Nanoliposome is an appropriate drug delivery system that can compensate for the limitations of traditional insoluble drugs, involving improvement of their solubility, stability and lipophilicity. In the present study, we comprised of OA covered with nanoliposomes, named OAnano, to observe antitumor effects on U87 glioma cells. The results showed that OAnano raised the solubility and oil-water partition coefficient. OAnano suppressed proliferation of U87 glioma cells, and also had an anticancer effect on U87 glioma cells, which was found to be higher than that of OA. Moreover, treatment with OAnano induced apoptosis and degraded migration ability by caspase-3 pathway. In conclusion, our results demonstrated that OA covered with nanoliposomes led to enhanced anticancer effects by suppressing proliferation, migration and invasion abilities. The findings may provide a reliable reference for development of new anti-cancer drugs.

Keywords: oleanolic acid, nano-particles, glioma cells, migration and invasion abilities, lipophilicity